An inhibitor of HECT E3 ubiquitin ligases
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Heclin

Item No. 26139

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(4-acetylphenyl)-3-(5-ethyl-2-furanyl)-2-propenamide
CAS Number
890605-54-6
Molecular Formula
C17H17NO3
Formula Weight
283.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 20 mg/mLEthanol: 10 mg/mL
λmax
224, 342 nm
SMILES
CC(C1=CC=C(NC(/C=C/C2=CC=C(CC)O2)=O)C=C1)=O
InChi Code
InChI=1S/C17H17NO3/c1-3-15-8-9-16(21-15)10-11-17(20)18-14-6-4-13(5-7-14)12(2)19/h4-11H,3H2,1-2H3,(H,18,20)/b11-10+
InChi Key
SPTWXRJNCFIDRQ-ZHACJKMWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $103

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    Product Description

    Heclin is an inhibitor of HECT E3 ubiquitin ligases (IC50s = 6.8, 6.3, and 6.9 μM for Smurf2, Nedd4, and WWP1 HECT ligase domains, respectively).1 It inhibits autoubiquitination of Smurf2 in HEK293 cells expressing the human enzyme (IC50 = 9 μM) and reduces ubiquitination of Dishevelled 2 in HEK293 cells expressing Smurf2, Nedd4, or WWP2. Heclin is cytotoxic to HEK293 cells (IC50 = 45 μM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mund, T., Lewis, M.J., Maslen, S., et al. Peptide and small molecule inhibitors of HECT-type ubiquitin ligases. Proc. Natl. Acad. Sci. USA 111(47), 16736-16741 (2014).