An inhibitor of Skp2-mediated p27 degradation
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SKPin C1

Item No. 26141

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[4-bromo-2-[[4-oxo-3-(3-pyridinylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]phenoxy]-acetic acid
CAS Number
432001-69-9
Molecular Formula
C18H13BrN2O4S2
Formula Weight
465.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 10 mg/mL
λmax
389 nm
SMILES
BrC1=CC=C(OCC(O)=O)C(/C=C2C(N(CC3=CC=CN=C3)C(S\2)=S)=O)=C1
InChi Code
InChI=1S/C18H13BrN2O4S2/c19-13-3-4-14(25-10-16(22)23)12(6-13)7-15-17(24)21(18(26)27-15)9-11-2-1-5-20-8-11/h1-8H,9-10H2,(H,22,23)/b15-7+
InChi Key
IYCJJVVXEHZJHE-VIZOYTHASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $91

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    10 mg

    $134

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    25 mg

    $266

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    Cayman Chemical
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    Product Description

    SKPin C1 is an inhibitor of Skp1-Cullin1-F-box (SCF) family protein Skp2-mediated p27 degradation.1 It binds to Skp2 at the Cdc kinase subunit 1 (Cks1) interaction interface and blocks ubiquitylation of p27 in a Cks1-dependent manner in vitro when used at a concentration of 50 μM. SKPin C1 increases nuclear accumulation of p27 in ECC-1 endometrial carcinoma cells.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wu, L., Grigoryan, A.V., Li, Y., et al. Specific small molecule inhibitors of Skp2-mediated p27 degradation. Chem. Biol. 19(12), 1515-1524 (2012).

    2. Pavlides, S.C., Huang, K.-T., Reid, D.A., et al. Inhibitors of SCF-Skp2/Cks1 E3 ligase block estrogen-induced growth stimulation and degradation of nuclear p27kip1: Therapeutic potential for endometrial cancer. Endocrinology 154(11), 4030-4045 (2013).