An inhibitor of Skp2
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SZL P1-41

Item No. 26142

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(2-benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one
CAS Number
222716-34-9
Molecular Formula
C24H24N2O3S
Formula Weight
420.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 0.3 mg/mlEthanol: 0.3 mg/ml
λmax
224, 264, 308
SMILES
O=C1C(C2=NC3=C(C=CC=C3)S2)=COC4=C1C=C(CC)C(O)=C4CN5CCCCC5
InChi Code
InChI=1S/C24H24N2O3S/c1-2-15-12-16-22(28)18(24-25-19-8-4-5-9-20(19)30-24)14-29-23(16)17(21(15)27)13-26-10-6-3-7-11-26/h4-5,8-9,12,14,27H,2-3,6-7,10-11,13H2,1H3
InChi Key
JKIXLEKBXHMXTN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $129

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    10 mg

    $231

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    25 mg

    $542

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    50 mg

    $1,016

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    Cayman Chemical
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    Product Description

    SZL P1-41 is an inhibitor of the Skp1-Cullin1-F-box (SCF) family protein Skp2.1 It inhibits the interaction between Skp2 and Skp1 to block Skp2 E3 ubiquitin ligase activity when used at a concentration of 5 μM. SZL P1-41 selectively inhibits Skp2 over Fbw7 and β-TrCP E3 ubiquitin ligase activity in HEK293T cells. It reduces survival of LNCaP and PC3 prostate cancer cells in a concentration-dependent manner via inhibition of aerobic glycolysis and induction of apoptosis. SZL P1-41 (40 and 80 mg/kg) reduces tumor volume in A549 lung cancer and PC3 prostate cancer mouse xenograft models.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chan, C.H., Morrow, J.K., Li, C.F., et al. Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression. Cell. 154(3), 556-568 (2013).