A derivative of paroxetine
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N-methyl Paroxetine

Item No. 26160

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-1-methyl-piperidine
CAS Number
110429-36-2
Synonyms
  • Paroxetine-Related Compound F
Molecular Formula
C20H22FNO3
Formula Weight
343.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 33 mg/mlDMF:PBS (pH 7) (1:10): 0.09 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/ml
λmax
235, 265, 271, 295 nm
SMILES
FC1=CC=C([C@H]2[C@H](COC3=CC(OCO4)=C4C=C3)CN(C)CC2)C=C1
InChi Code
InChI=1S/C20H22FNO3/c1-22-9-8-18(14-2-4-16(21)5-3-14)15(11-22)12-23-17-6-7-19-20(10-17)25-13-24-19/h2-7,10,15,18H,8-9,11-13H2,1H3/t15-,18-/m0/s1
InChi Key
MOJZPKOBKCXNKG-YJBOKZPZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 mg

    $98

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    500 mg

    $186

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    1 g

    $294

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    5 g

    $1,371

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    Product Description

    N-methyl Paroxetine is a derivative of the selective serotonin reuptake inhibitor (SSRI) antidepressant paroxetine (Item No. 14998) that inhibits [3H]paroxetine binding to rat cortical membranes (Ki = 4.3 nM).1 It inhibits serotonin (5-HT; Item No. 14332) uptake in rat brain synaptosomes with an IC50 value of 22 nM.2 N-methyl Paroxetine has been used as a precursor in the synthesis of paroxetine and is a potential impurity in commercial preparations of paroxetine.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mathis, C.A., Gerdes, J.M., Enas, J.D., et al. Binding potency of paroxetine analogues for the 5-hydroxytryptamine uptake complex. J. Pharm. Pharmacol. 44(10), 801-805 (1992).

    2. Plenge, P., Mellerup, E.T., Honoré, T., et al. The activity of 25 paroxetine/femoxetine structure variants in various reactions, assumed to be important for the effect of antidepressants. J. Pharm. Pharmacol. 39(11), 877-882 (1987).

    3. Konudula, B.R., Lahiri, S., Rawat, G.S., et al. Process for the preparation of paroxetine hydrochloride. (2009).