An Aurora A kinase inhibitor
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MK-8745

Item No. 26190

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3-chloro-2-fluorophenyl)[4-[[6-(2-thiazolylamino)-2-pyridinyl]methyl]-1-piperazinyl]-methanone
CAS Number
885325-71-3
Molecular Formula
C20H19ClFN5OS
Formula Weight
431.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 20 mg/ml
λmax
274, 318 nm
SMILES
ClC1=CC=CC(C(N2CCN(CC3=NC(NC4=NC=CS4)=CC=C3)CC2)=O)=C1F
InChi Code
InChI=1S/C20H19ClFN5OS/c21-16-5-2-4-15(18(16)22)19(28)27-10-8-26(9-11-27)13-14-3-1-6-17(24-14)25-20-23-7-12-29-20/h1-7,12H,8-11,13H2,(H,23,24,25)
InChi Key
YCRFPWKUUNKNDN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $54

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    10 mg

    $96

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    25 mg

    $209

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    50 mg

    $315

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    Product Description

    MK-8745 is an Aurora A kinase inhibitor (IC50 = 0.6 nM) that is selective for Aurora A over Aurora B kinase (IC50 = 280 nM).1 It induces cell cycle arrest at the G2/M phase in non-Hodgkin lymphoma cells when used at a concentration of 1 μM.2 MK-8745 (5 μM) induces apoptosis and polyploidy in p53-positive and -negative HCT116 colon cancer cells, respectively.1 It also induces apoptosis in sarcoma, melanoma, and pancreatic cancer cell lines in a p53-dependent manner when used at a concentration of 5 μM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nair, J.S., Ho, A.L., and Schwartz, G.K. The induction of polyploidy or apoptosis by the Aurora A kinase inhibitor MK8745 is p53-dependent. Cell Cycle 11(4), 807-817 (2012).

    2. Chowdhury, A., Chowdhury, S., and Tsai, M.Y. A novel Aurora kinase A inhibitor MK-8745 predicts TPX2 as a therapeutic biomarker in non-Hodgkin lymphoma cell lines. Leuk. Lymphoma 53(3), 462-471 (2012).