(E)-Ajoene

(E)-Ajoene is a disulfide that has been found in A. sativum and has diverse biological activities.^1,2,3,4 It is active against Gram-positive and Gram-negative bacteria (MICs = 10-250 and 150->500 µg/ml, respectively) and fungi (MICs = 15-50 µg/ml).¹ (E)-Ajoene inhibits proliferation of a variety of cancer cells, including MDA-MB-231 breast, HeLa cervical, and WHCO1 esophageal cancer cells (IC₅₀s = 18.6, 61, and 39.2 µM, respectively).² It also inhibits human glutathione reductase and T. cruzi trypanothione reductase when used at a concentration of 200 µM.³ (E)-Ajoene (25 mg/kg) is neuroprotective in a gerbil model of ischemia-reperfusion injury, reducing reactive astrocytosis and microgliosis in the hippocampal CA1 region.⁴

WARNING This product is not for human or veterinary use.

1. Yoshida, H., Iwata, N., Katsuzaki, H., et al. Antimicrobial activity of a compound isolated from an oil-macerated garlic extract. Biosci. Biotechnol. Biochem. 62(5), 1014-1017 (1998).

2. Kaschula, C.H., Hunter, R., Hassan, H.T., et al. Anti-proliferation activity of synthetic ajoene analogues on cancer cell-lines. Anticancer Agents Med. Chem. 11(3), 260-266 (2011).

3. Gallwitz, H., Bonse, S., Martinez-Cruz, A., et al. Ajoene is an inhibitor and subversive substrate of human glutathione reductase and Trypanosoma cruzi trypanothione reductase: Crystallographic, kinetic, and spectroscopic studies. J. Med. Chem. 42(3), 364-372 (1999).

4. Yoo, D.Y., Kim, W., Nam, S.M., et al. Neuroprotective effects of Z-ajoene, an organosulfur compound derived from oil-macerated garlic, in the gerbil hippocampal CA1 region after transient forebrain ischemia. Food Chem. Toxicol. 72, 1-7 (2014).