(E/Z)-Ajoene

(E/Z)-Ajoene is a disulfide that has been found in A. sativum and has antitumor and antiplatelet activities.^1,2 It is cytotoxic to a variety of cancer cells, including B16-BL6 murine melanoma, and human HT-29 colon adenocarcinoma, MDA-MB-231 mammary, and PANC-1 pancreatic adenocarcinoma cells (IC₅₀s = 18, 19, 7, and 38 µM, respectively).¹ (E/Z)-Ajoene (25 mg/kg) reduces tumor growth and decreases the number of lung metastases in B16-BL6 murine models of melanoma. It also prevents thrombus formation in heparinized animals in a porcine model of severe vascular damage induced by intimal stripping and tunica media exposure when administered at a dose of 25 mg/kg.²

WARNING This product is not for human or veterinary use.

1. Taylor, P., Noriega, R., Farah, C., et al. Ajoene inhibits both primary tumor growth and metastasis of B16/BL6 melanoma cells in C57BL/6 mice. Cancer Lett. 239(2), 298-304 (2006).

2. Apitz-Castro, R., Badimon, J.J., and Badimon, L. A garlic derivative, ajoene, inhibits platelet deposition on severely damaged vessel wall in an in vivo porcine experimental model. Thromb. Res. 75(3), 243-249 (1994).