An adenosine A2 receptor antagonist
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Product Type

Small Molecule Modulators
Receptor Pharmacology
Antagonists

Research Area

Cancer

AZD 4635

Item No. 26322

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-(2-chloro-6-methyl-4-pyridinyl)-5-(4-fluorophenyl)-1,2,4-triazin-3-amine
CAS Number
1321514-06-0
Synonyms
  • HTL-1071
  • Imaradenant
Molecular Formula
C15H11ClFN5
Formula Weight
315.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml
λmax
273, 304 nm
SMILES
NC1=NC(C2=CC=C(F)C=C2)=C(C3=CC(C)=NC(Cl)=C3)N=N1
InChi Code
InChI=1S/C15H11ClFN5/c1-8-6-10(7-12(16)19-8)14-13(20-15(18)22-21-14)9-2-4-11(17)5-3-9/h2-7H,1H3,(H2,18,20,22)
InChi Key
NCWQLHHDGDXIJN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    50 mg

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    Cayman Chemical
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    Product Description

    AZD 4635 is an adenosine A2 receptor antagonist (Ki = 1.7 nM for the human receptor).1 It inhibits adenosine-induced cAMP production in CHO cells expressing the human A2 receptor (IC50 = 0.79 μM) and reverses suppression of IFN-γ secretion induced by 5'-N-ethylcarboxamidoadenosine (NECA; Item No. 21420) in CD8+ T cells. AZD 4635 reduces tumor growth when administered alone and in combination with checkpoint inhibitors in syngeneic mouse tumor models.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Borodovsky, A., Wang, Y., Ye, M., et al. Abstract 5580: Preclinical pharmacodynamics and antitumor activity of AZD4635, a novel adenosine 2A receptor inhibitor that reverses adenosine mediated T cell suppression. Cancer Res. 77(13 Supp.), 5580 (2017).