Pricing updated 2019-07-17. Prices are subject to change without notice.
WAY-316606 is an inhibitor of secreted frizzled-related protein 1 (sFRP-1; IC50 = 0.5 μM).1 It increases Wnt signaling in U2OS osteosarcoma cells (EC50 = 0.65 μM). WAY-316606 increases total bone area in a murine calvarial organ culture assay when used at concentrations greater than 0.1 nM.2
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Moore, W.J., Kern, J.C., Bhat, R., et al. Modulation of Wnt signaling through inhibition of secreted frizzled-
Bodine, P.V., Stauffer, B., Ponce-