A positive allosteric modulator of M2 and M4 mAChRs
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LY2119620

Item No. 26373

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methyl-1-piperazinyl)-2-oxoethoxy]-thieno[2,3-b]pyridine-2-carboxamide
CAS Number
886047-22-9
Molecular Formula
C19H24ClN5O3S
Formula Weight
437.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 50 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.33 mg/mlEthanol: 1 mg/ml
λmax
291 nm
SMILES
CN1CCN(C(COC2=NC(SC(C(NC3CC3)=O)=C4N)=C4C(C)=C2Cl)=O)CC1
InChi Code
InChI=1S/C19H24ClN5O3S/c1-10-13-15(21)16(17(27)22-11-3-4-11)29-19(13)23-18(14(10)20)28-9-12(26)25-7-5-24(2)6-8-25/h11H,3-9,21H2,1-2H3,(H,22,27)
InChi Key
TYTGOXSAAQWLPJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    Product Description

    LY2119620 is a positive allosteric modulator of the M2 and M4 muscarinic acetylcholine receptors (mAChRs).1 It binds to allosteric sites on M2 and M4 receptors with KB values ranging from 1.8 to 3.4 μM. LY2119620 potentiates the activity of the AChR agonist acetylcholine (ACh; Item No. 23829) and the mAChR agonists iperoxo and oxotremorine M (Item No. 20847) at human recombinant M2 and M4 receptors expressed in CHO cell membranes. LY2119620 also exhibits allosteric agonism at M2 and M4 receptors (23.2 and 16.8%, respectively, of the maximal ACh response).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Croy, C.H., Schober, D.A., Xiao, H., et al. Characterization of the novel positive allosteric modulator, LY2119620, at the muscarinic M2 and M4 receptors. Mol. Pharmacol. 86(1), 106-115 (2014).