An ATM kinase inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

AZ 32

Item No. 26380

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)-benzamide
CAS Number
2288709-96-4
Molecular Formula
C20H16N4O
Formula Weight
328.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 150 mg/ml
SMILES
O=C(NC)C1=CC=C(C2=CN=C3N2C=C(C4=CC=CC=C4)N=C3)C=C1
InChi Code
InChI=1S/C20H16N4O/c1-21-20(25)16-9-7-15(8-10-16)18-11-23-19-12-22-17(13-24(18)19)14-5-3-2-4-6-14/h2-13H,1H3,(H,21,25)
InChi Key
LCRTUEXVVKVKBD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $41

    Add

    5 mg

    $186

    Add

    10 mg

    $312

    Add

    25 mg

    $583

    Add
    Kinase Resource Center
    Discover Products & Resources for Kinase Research
    • Kinase inhibitors, screening libraries, assay kits, & more
    • Tools to study kinase signaling pathways:
      • Growth factor signaling
      • PI3K/Akt/mTOR
      • MAPKs (ERK, p38, & JNK)
      • JAK/STAT signaling
    • Articles, resources, & advice
    EXPLORE NOW
    Product Description

    AZ 32 is an inhibitor of ataxia-telangiectasia mutated (ATM) kinase (IC50 = <6.2 nM).1 It is selective for ATM over PI3Kα and ataxia-telangiectasia and Rad3-related (ATR) kinase (IC50s = 4.6 and >4.6 µM, respectively). AZ 32 enhances radiation-induced cytotoxicity in a panel of five human glioma cells expressing wild-type or mutant p53. It increases survival in a U87-281G glioma orthotopic mouse xenograft model, as well as a NCI H2228 non-small cell lung cancer (NSCLC) mouse xenograft model of metastatic brain tumors, when administered at doses of 200 and 50 mg/kg, respectively, in combination with ionizing radiation.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Karlin, J., Allen, J., Ahmad, S.F., et al. Orally bioavailable and blood-brain barrier-penetrating ATM inhibitor (AZ32) radiosensitizes intracranial gliomas in mice. Mol. Cancer Ther. 17(8), 1637-1647 (2018).