An iridoid glycoside with diverse biological activities
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Specnuezhenide

Item No. 26385

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(4-hydroxyphenyl)ethyl, 6-[(2S,3Z,4S)-3-ethylidene-2-(β-D-glucopyranosyloxy)-3,4-dihydro-5-(methoxycarbonyl)-2H-pyran-4-acetate], β-D-glucopyranoside
CAS Number
449733-84-0
Synonyms
  • 8(Z)-Nuzhenide
Molecular Formula
C31H42O17
Formula Weight
686.7
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 14 mg/mlEthanol: 17 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
227 nm
SMILES
OC[C@H]1O[C@](O[C@@H]2OC=C(C(OC)=O)[C@@H](CC(OC[C@H]3O[C@@H](OCCC4=CC=C(O)C=C4)[C@H](O)[C@@H](O)[C@@H]3O)=O)/C2=C/C)([H])[C@H](O)[C@@H](O)[C@@H]1O
InChi Code
InChI=1S/C31H42O17/c1-3-16-17(18(28(41)42-2)12-45-29(16)48-31-27(40)24(37)22(35)19(11-32)46-31)10-21(34)44-13-20-23(36)25(38)26(39)30(47-20)43-9-8-14-4-6-15(33)7-5-14/h3-7,12,17,19-20,22-27,29-33,35-40H,8-11,13H2,1-2H3/b16-3-/t17-,19+,20+,22+,23+,24-,25-,26+,27+,29-,30+,31-/m0/s1
InChi Key
STKUCSFEBXPTAY-GSUVRYNNSA-N
Origin
Plant/Ligustrum lucidum
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    Product Description

    Specneuzhenide is an iridoid glycoside originally isolated from L. lucidum with diverse biological activities.1,2,3,4 It reduces neurotoxicity induced by 6-OHDA (Item No. 25330) in SH-SY5Y cells by 49.2% when used at a concentration of 10 μM.1 Specneuzhenide (25, 50, and 100 μM) reduces high glucose-induced levels of cleaved caspase-3 protein and apoptosis in mouse glomerular mesangial cells.2 It increases cell viability and alkaline phosphatase activity in osteoblastic UMR-106 cells.3 Specneuzhenide inhibits hypoxia-induced VEGFA secretion, VEGFA and prolyl hydroxylase 2 (PHD-2) mRNA expression, and protein levels of VEGFA, HIF-1α, and PHD-2 in human acute retinal pigment epithelial-19 (ARPE-19) cells.4 In vivo, specneuzhenide (5 and 10 mg/kg) prevents retinal neovascularization in a rat model of oxygen-induced retinopathy.

    WARNING This product is not for human or veterinary use.