An internal standard for the quantification of tolvaptan
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Unlabeled Version(s)
19691Tolvaptan
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Tolvaptan-d7

Item No. 26453

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-[(7-chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-6-(methyl-d3)-benzamide-2,3,4,5-d4
CAS Number
1246818-18-7
Molecular Formula
C26H18ClD7N2O3
Formula Weight
456.0
Purity
≥99% deuterated forms (d1-d7)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly solubleMethanol: Slightly soluble
SMILES
O=C(NC1=CC(C)=C(C(N2C(C=CC(Cl)=C3)=C3C(O)CCC2)=O)C=C1)C4=C(C([2H])([2H])[2H])C([2H])=C([2H])C([2H])=C4[2H]
InChi Code
InChI=1S/C26H25ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-19)26(32)29-13-5-8-24(30)22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15,24,30H,5,8,13H2,1-2H3,(H,28,31)/i1D3,3D,4D,6D,7D
InChi Key
GYHCTFXIZSNGJT-FFQSSJIFSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    2.5 mg

    $362

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    Product Description

    Tolvaptan-d7 is intended for use as an internal standard for the quantification of tolvaptan (Item No. 19691) by GC- or LC-MS. Tolvaptan is a nonpeptide vasopressin V2 receptor antagonist (IC50 = 3 nM for rat receptor) and a diuretic agent.1 It is selective for V2 over V1 receptors (IC50 = 0.58 μM). Tolvaptan increases urine volume by 3-fold in rats when administered at a dose of 0.54 mg/kg. It also reduces left ventricular end-systolic volumes and improves left ventricular ejection fraction in a rat model of myocardial infarction.2 Formulations containing tolvaptan have been used to treat hyponatremia.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kondo, K., Ogawa, H., Yamashita, H., et al. 7-Chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoyl-amino)benzoyl ]-2,3,4,5-tetrahydro-1H-1-benzazepine (OPC-41061): A potent, orally active nonpeptide arginine vasopressin V2 receptor antagonist. Bioorg. Med. Chem. 7(8), 1743-1754 (1999).

    2. Yamazaki, T., Nakamura, Y., Shiota, M., et al. Tolvaptan attenuates left ventricular fibrosis after acute myocardial infarction in rats. J. Pharmacol. Sci. 123(1), 58-66 (2013).