An internal standard for the quantification of ketorolac
Related Products
Unlabeled Version(s)
9001148Ketorolac 9003475Ketorolac (calcium salt)
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Ketorolac-d5

Item No. 26454

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(benzoyl-d5)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
CAS Number
1215767-66-0
Molecular Formula
C15H8D5NO3
Formula Weight
260.3
Purity
≥99% deuterated forms (d1-d5)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: slightly solubleMethanol: slightly soluble
SMILES
O=C(C1=CC=C2N1CCC2C(O)=O)C3=C([2H])C([2H])=C([2H])C([2H])=C3[2H]
InChi Code
InChI=1S/C15H13NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13/h1-7,11H,8-9H2,(H,18,19)/i1D,2D,3D,4D,5D
InChi Key
OZWKMVRBQXNZKK-RALIUCGRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $213

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    1 mg

    $402

    Add
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    Product Description

    Ketorolac-d5 is intended for use as an internal standard for the quantification of ketorolac (Item No. 9001148) by GC- or LC-MS. Ketorolac is a non-steroidal anti-inflammatory drug (NSAID) and a non-selective COX inhibitor (IC50 = 20 nM for both COX-1 and COX-2).1 It prevents increases in paw swelling, increases paw withdrawal latency in a hot-plate test, and decreases prostaglandin E2 (PGE2) levels in paw tissue in a mouse model of carrageenan-induced inflammation when administered at a dose of 30 mg/kg. Ketorolac is a racemic mixture containing the active (S)-ketorolac (Item No. 11348) and inactive (R)-ketorolac enantiomers. Formulations containing ketorolac have been used to manage postoperative pain and as ophthalmic solutions to treat ocular pain and inflammation.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, Y., Shaffer, A., Portanova, J., et al. Inhibition of cyclooxygenase-2 rapidly reverses inflammatory hyperalgesia and prostaglandin E2 production. J. Pharmacol. Exp. Ther. 283(3), 1069-1075 (1997).