An NSAID and COX inhibitor
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Ketorolac

Item No. 9001148

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
CAS Number
74103-06-3
Synonyms
  • RS 37619
Molecular Formula
C15H13NO3
Formula Weight
255.3
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
Ethanol: > 1 mg/ml
λmax
245, 312 nm
SMILES
O=C(C1=CC=C2N1CCC2C(O)=O)C3=CC=CC=C3
InChi Code
InChI=1S/C15H13NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13/h1-7,11H,8-9H2,(H,18,19)
InChi Key
OZWKMVRBQXNZKK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    50 mg

    $17

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    100 mg

    $21

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    500 mg

    $87

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    1 g

    $121

    Add
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    Product Description

    Ketorolac is a non-steroidal anti-inflammatory drug (NSAID) and a non-selective COX inhibitor (IC50 = 20 nM for both COX-1 and COX-2).1 It prevents increases in paw swelling, increases paw withdrawal latency in a hot-plate test, and decreases prostaglandin E2 (PGE2) levels in paw tissue in a mouse model of carrageenan-induced inflammation when administered at a dose of 30 mg/kg. Ketorolac is a racemic mixture containing the active (S)-ketorolac (Item No. 11348) and inactive (R)-ketorolac enantiomers. Formulations containing ketorolac have been used to manage postoperative pain and as ophthalmic solutions to treat ocular pain and inflammation.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, Y., Shaffer, A., Portanova, J., et al. Inhibition of cyclooxygenase-2 rapidly reverses inflammatory hyperalgesia and prostaglandin E2 production. J. Pharmacol. Exp. Ther. 283(3), 1069-1075 (1997).

    Product Citations

    Zhang, Y., Shaffer, A., Portanova, J., et al. Inhibition of cyclooxygenase-2 rapidly reverses inflammatory hyperalgesia and prostaglandin E2 production. J. Pharmacol. Exp. Ther. 283(3), 1069-1075 (1997).