An internal standard for the quantification of hydrocortisone
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Unlabeled Version(s)
20739Hydrocortisone
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Hydrocortisone-d4

Item No. 26500

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(11β)-11,17,21-trihydroxy-pregn-4-ene-3,20-dione-9,11,12,12-d4
CAS Number
73565-87-4
Synonyms
  • Cortisol-d4
Molecular Formula
C21H26D4O5
Formula Weight
366.5
Purity
≥99% deuterated forms (d1-d4)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:4): 0.2 mg/mlDMSO: 20 mg/mlEthanol: 2 mg/ml
SMILES
O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@]2([2H])[C@](O)([2H])C([2H])([2H])[C@@]4(C)[C@@]3([H])CC[C@]4(O)C(CO)=O)=C1
InChi Code
InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1/i10D2,16D,18D
InChi Key
JYGXADMDTFJGBT-BJJKTIQHSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $103

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    1 mg

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    5 mg

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    Product Description

    Hydrocortisone-d4 is intended for use as an internal standard for the quantification of hydrocortisone/cortisol (Item No. 20739) by GC- or LC-MS. Cortisol, known as hydrocortisone when used as a therapeutic, is a glucocorticoid produced by the adrenal cortex in response to adrenocorticotropic hormone (ACTH).1,2 It is an agonist at the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR), with an approximately 6- to 10-fold greater affinity for MR. Cortisol production is increased during periods of stress, and it is a major effector molecule in the hypothalamic-pituitary-adrenal axis (HPA) stress response.2 Cortisol levels increase with age and are often elevated in major depressive disorder, certain forms of hypertension, and Parkinson's disease.3,4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Krieger, D.T. Rhythms of ACTH and corticosteroid secretion in health and disease, and their experimental modification. J. Steroid Biochem. 6(5), 785-791 (1975).

    2. Dunlop, B.W., and Wong, A. The hypothalamic-pituitary-adrenal axis in PTSD: Pathophysiology and treatment interventions. Prog. Neuropsychopharmacol. Biol. Psychiatry 89, 361-379 (2019).

    3. Quinkler, M., and Stewart, P.M. Hypertension and the cortisol-cortisone shuttle. J. Clin. Endocrinol. Metab. 88(6), 2384-2392 (2003).

    4. Varghese, F.P., and Brown, E.S. The hypothalamic-pituitary-adrenal axis in major depressive disorder: A brief primer for primary care physicians. Prim. Care Companion J. Clin. Psychiatry 3(4), 151-155 (2001).

    5. Soares, N.M., Pereira, G.M., Altmann, V., et al. Cortisol levels, motor, cognitive and behavioral symptoms in Parkinson’s disease: A systematic review. J. Neural Transm. (Vienna) (2018).