A glucocorticoid
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Hydrocortisone

Item No. 20739

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(11β)-11,17,21-trihydroxy-pregn-4-ene-3,20-dione
CAS Number
50-23-7
Synonyms
  • Cortisol
  • Dihydrocostisone
  • NSC 10483
Molecular Formula
C21H30O5
Formula Weight
362.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:4): 0.20 mg/mlDMSO: 20 mg/mlEthanol: 2 mg/ml
λmax
242 nm
SMILES
[H][C@]12[C@@]([C@@](CC[C@]3(O)C(CO)=O)([H])[C@]3(C)C[C@@H]2O)([H])CCC4=CC(CC[C@@]41C)=O
InChi Code
InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
InChi Key
JYGXADMDTFJGBT-VWUMJDOOSA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $33

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    10 g

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    25 g

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    Product Description

    Cortisol, known as hydrocortisone when used as a therapeutic, is a glucocorticoid produced by the adrenal cortex in response to adrenocorticotropic hormone (ACTH).1,2 It is an agonist at the mineralocorticoid receptor (MR) and the glucocorticoid receptor, with an approximately 6- to 10-fold greater affinity for MR. Cortisol production is increased during periods of stress, and it is a major effector molecule in the hypothalamic-pituitary-adrenal axis (HPA) stress response.2 Cortisol levels increase with age and are often elevated in major depressive disorder, certain forms of hypertension, and Parkinson’s disease.3,4,5 This product is also available as part of Cayman's Hepatocyte Differentiation Reagent Kit (Item No. 44737).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Krieger, D.T. Rhythms of ACTH and corticosteroid secretion in health and disease, and their experimental modification. J. Steroid Biochem. 6(5), 785-791 (1975).

    2. Dunlop, B.W., and Wong, A. The hypothalamic-pituitary-adrenal axis in PTSD: Pathophysiology and treatment interventions. Prog. Neuropsychopharmacol. Biol. Psychiatry 89, 361-379 (2019).

    3. Quinkler, M., and Stewart, P.M. Hypertension and the cortisol-cortisone shuttle. J. Clin. Endocrinol. Metab. 88(6), 2384-2392 (2003).

    4. Varghese, F.P., and Brown, E.S. The hypothalamic-pituitary-adrenal axis in major depressive disorder: A brief primer for primary care physicians. Prim. Care Companion J. Clin. Psychiatry 3(4), 151-155 (2001).

    5. Soares, N.M., Pereira, G.M., Altmann, V., et al. Cortisol levels, motor, cognitive and behavioral symptoms in Parkinson’s disease: A systematic review. J. Neural Transm. (Vienna) (2018).