A ferroptosis inhibitor
Related Products
Alternative(s)
29346UAMC-3203 (hydrochloride)
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Product Categories

Product Type

Biochemicals

Research Area

Cell Biology
Cell Death
Ferroptosis

UAMC-3203

Item No. 26525

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(cyclohexylamino)-3-[(phenylmethyl)amino]-N-[2-(1-piperazinyl)ethyl]-benzenesulfonamide
CAS Number
2271358-64-4
Molecular Formula
C25H37N5O2S
Formula Weight
471.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble
λmax
237, 286 nm
SMILES
O=S(C(C=C1NCC2=CC=CC=C2)=CC=C1NC3CCCCC3)(NCCN4CCNCC4)=O
InChi Code
InChI=1S/C25H37N5O2S/c31-33(32,28-15-18-30-16-13-26-14-17-30)23-11-12-24(29-22-9-5-2-6-10-22)25(19-23)27-20-21-7-3-1-4-8-21/h1,3-4,7-8,11-12,19,22,26-29H,2,5-6,9-10,13-18,20H2
InChi Key
HSYSVXKJIVUNBR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $120

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    10 mg

    $169

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    25 mg

    $336

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    Product Description

    UAMC-3203 is an inhibitor of ferroptosis that has an IC50 value of 10 nM for inhibition of erastin-induced ferroptosis in IMR-32 neuroblastoma cells.1 It decreases iron-induced plasma lactate dehydrogenase (LDH) levels in a mouse model of acute iron poisoning when administered at a dose of 20 µmol/kg. It is not toxic to mice following chronic administration of a 20 µmol/kg dose for four weeks. UAMC-3203 has increased solubility and a longer half-life in mouse, rat, and human microsomes and isolated plasma than the ferroptosis inhibitor ferrostatin-1 (Item No. 17729). In an in silico membrane dynamics study, UAMC-3203 was incorporated into a phospholipid bilayer.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Devisscher, L., Van Coillie, S., Hofmans, S., et al. Discovery of novel, drug-like ferroptosis inhibitors with in vivo efficacy. J. Med. Chem. 61(22), 10126-10140 (2018).