An ATR inhibitor
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Alternative(s)
33603BAY-1895344
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BAY-1895344 (hydrochloride)

Item No. 26536

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(3R)-3-methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-3-yl)-1,7-naphthyridine, monohydrochloride
Molecular Formula
C20H21N7O • HCl
Formula Weight
411.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 30 mg/mlEthanol: 30 mg/mlWater: 30 mg/ml
λmax
256, 296, 431 nm
SMILES
C[C@H](COCC1)N1C2=NC3=C(C4=NNC=C4)N=CC=C3C(C5=CC=NN5C)=C2.Cl
InChi Code
InChI=1S/C20H21N7O.ClH/c1-13-12-28-10-9-27(13)18-11-15(17-5-8-23-26(17)2)14-3-6-21-20(19(14)24-18)16-4-7-22-25-16;/h3-8,11,13H,9-10,12H2,1-2H3,(H,22,25);1H/t13-;/m1./s1
InChi Key
KWQNBYGUBHMRPY-BTQNPOSSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $54

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    5 mg

    $178

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    10 mg

    $293

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    25 mg

    $680

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    Product Description

    BAY-1895344 is an inhibitor of ataxia-telangiectasia and Rad3-related protein (ATR) kinase that inhibits proliferation in a panel of human tumor cell lines (mean IC50 = 78 nM).1 It halts tumor growth in ovarian and colorectal mouse xenograft models and induces complete tumor remission in mantle cell lymphoma mouse xenograft models. BAY-1895344 also exhibits synergistic anti-tumor activity with radium-223 in a mouse xenograft model of castration-resistant prostate cancer bone metastases.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wengner, A.M., Siemeister, G., Luecking, U., et al. Abstract 836: ATR inhibitor BAY 1895344 shows potent anti-tumor efficacy in monotherapy and strong combination potential with the targeted alpha therapy Radium-223 dichloride in preclinical tumor models. Cancer Res. 77(13 Suppl), 836-836 (2017).