A cationic cholesterol derivative
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DMPAC-Chol

Item No. 26583

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β)-cholest-5-en-3-ol 3-[[3-(dimethylamino)propyl]carbamate]
CAS Number
184582-91-0
Synonyms
  • Chol-T
Molecular Formula
C33H58N2O2
Formula Weight
514.8
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlEthanol: 10 mg/mlEthanol:PBS (pH 7.2) (1:6): 0.14 mg/ml
SMILES
C[C@H](CCCC(C)C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](OC(NCCCN(C)C)=O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
InChi Code
InChI=1S/C33H58N2O2/c1-23(2)10-8-11-24(3)28-14-15-29-27-13-12-25-22-26(37-31(36)34-20-9-21-35(6)7)16-18-32(25,4)30(27)17-19-33(28,29)5/h12,23-24,26-30H,8-11,13-22H2,1-7H3,(H,34,36)/t24-,26+,27+,28-,29+,30+,32+,33-/m1/s1
InChi Key
KXWSSROBKRIZBR-FLFWOSPYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    Product Description

    DMPAC-Chol is a cationic cholesterol derivative that has been used in liposome formation for gene transfection.1 Liposomes containing DMPAC-chol bind to DNA in a band shift assay and protect against serum nuclease degradation of DNA when used at lipsome:DNA ratios ranging from 2.5:1 to 10:1 w/w. DMPAC-Chol-containing liposomes also reduce viability of HepG2 cells by 63% when used at a concentration of 37.5 µg/ml.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kisoon, N., Ariatti, M., and Moodley, T. A novel cationic cholesterol derivative, its formulation into liposomes, and the efficient transfection of the transformed human cell lines HepG2 and HeLa. Drug Deliv. 9(3), 161-167 (2002).