LIPID NANOPARTICLE TOOLS & RESOURCES

Lipid nanoparticles (LNPs) are customizable platforms built from lipids used for the delivery of nucleic acid therapies. They offer significant advantages over existing methods, including increased drug stability, improved delivery, and targeted distribution. For these reasons, LNPs have great potential to revolutionize the development of new therapeutics beyond infectious disease.

Lipids for LNP Formulation

The use of high-purity lipids is critical for the success of an LNP. Browse our extensive and continuously expanding catalog of ready-made lipids that can be used to form LNPs. Custom design and synthesis of novel lipids is also available.

Cationic Lipids

Fixed and ionizable cationic lipids are used in LNPs to encapsulate nucleic acid and promote endosomal escape.

Helper Lipids

Anionic lipids prevent particle aggregation during storage and can be used to modify the net surface charge of the LNP.

Neutral phospholipids have a role in membrane fusion and can be used to modify the net surface charge of the LNP.

PEGylated Lipids

PEGylated lipids prevent opsonization, improving particle stability and increasing bioavailability.

Sterol Lipids

Sterol lipids provide stability to LNPs and promote membrane fusion and endosomal escape.

Formulation Guidance from Our Lipid Experts

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LipidLaunch™ Research Tools for RNA Delivery

Explore LNPs in a simple and cost-effective way with our LipidLaunch™ research-ready LNPs and reagent kits. From discovery to bioanalysis, we offer a range of purpose-built solutions to support your LNP expedition – whether just testing the waters or exploring the deep.

Preloaded LNPs

Start here with preformulated LNPs containing reporter gene mRNA. Suitable for pilot and proof-of-concept experiments to help identify target cell feasibility and preliminary LNP culture conditions.

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Loadable LNPs

Get a first impression of your target of interest. These cargo-ready, loadable LNPs enable researchers to encapsulate and transfect cells with their RNA cargo of choice.

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LNP Exploration Kits

Prepare your own LNPs with adaptable protocols suited for a range of specialized-to-basic equipment. Make and add LNPs to cells and analyze for biological readouts of interest.

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LNP Uptake Kits

Visualize uptake of your LNP preparation in your target cells with sterol-based fluorescent tracers. Compatible with other biological readouts.

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Explore how our LipidLaunch™ research tools simplify discovery across the LNP pipeline.

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LNP Development Services

Cayman provides integrated solutions for custom LNP development combining our industry-leading expertise in lipid chemistry, synthesis, and analysis with proficiencies in bioanalysis and cell biology.

Custom Lipid
Synthesis

Custom synthesis of high-purity lipids from smaller batch sizes to larger scale GMP quantities.

LNP Formulation &
Characterization

Microfluidic LNP preparation and comprehensive particle characterization and stability testing.

LNP Bioanalysis &
Screening

Bioanalytical services for in vitro assessment of payload delivery and downstream biological effects.

What Can We Help You Discover?

Learn more about our full range of LNP development services and contact us to discuss how our experts can help customize a program that fits your unique project requirements.

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