A major metabolite of ibuprofen
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Ibuprofen Carboxylic Acid

Item No. 26594

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(2-carboxypropyl)-α-methyl-benzeneacetic acid
CAS Number
15935-54-3
Synonyms
  • Carboxyibuprofen
Molecular Formula
C13H16O4
Formula Weight
236.3
Purity
≥98% (mixture of diastereomers)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: solubleEthyl Acetate: soluble
SMILES
CC(C(O)=O)C1=CC=C(CC(C)C(O)=O)C=C1
InChi Code
InChI=1S/C13H16O4/c1-8(12(14)15)7-10-3-5-11(6-4-10)9(2)13(16)17/h3-6,8-9H,7H2,1-2H3,(H,14,15)(H,16,17)
InChi Key
DIVLBIVDYADZPL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $69

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    1 mg

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    Product Description

    Ibuprofen carboxylic acid is a major metabolite of ibuprofen (Item Nos. 70280 | 16793 | 16794).1 It prevents fructose-, cyanate-, and prednisolone-induced inactivation of catalase and fructose- and cyanate-induced inactivation of fumarase when used at a concentration of 2 mM and penetrates into the lens of isolated bovine eyes.2 Ibuprofen carboxylic acid has been found in bank filtrate and surface water, as well as influent and effluent wastewater, and is considered a micropollutant.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mills, R.F., Adams, S.S., Cliffe, E.E., et al. The metabolism of ibuprofen. Xenobiotica 3(9), 589-598 (1973).

    2. Shyadehi, A.Z., and Harding, J.J. Protective effects of ibuprofen and its major metabolites against in vitro inactivation of catalase and fumarase: Relevance to cataract. Biochim. Biophys. Acta 1587(1), 31-35 (2002).

    3. Hermes, N., Jewell, K.S., Wick, A., et al. Quantification of more than 150 micropollutants including transformation products in aqueous samples by liquid chromatography-tandem mass spectrometry using scheduled multiple reaction monitoring. J. Chromatogr. A. 1531, 64-73 (2018).