A phenolic acid with anti-inflammatory and anti-steatotic activities
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4-Hydroxyphenylacetic Acid

Item No. 26613

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-hydroxy-benzeneacetic acid
CAS Number
156-38-7
Synonyms
  • 4-HPAA
  • p-HPAA
  • para-HPAA
  • p-Hydroxyphenylacetic Acid
  • para-Hydroxyphenylacetic Acid
  • NSC 25066
  • NSC 27460
Molecular Formula
C8H8O3
Formula Weight
152.1
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
OC1=CC=C(CC(O)=O)C=C1
InChi Code
InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)
InChi Key
XQXPVVBIMDBYFF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 g

    $41

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    50 g

    $75

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    100 g

    $119

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    250 g

    $215

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    4-Hydroxyphenylacetic acid is a phenolic acid with anti-inflammatory and anti-steatotic activities.1,2 It is formed via microbial metabolism of aromatic amino acids and polyphenolic compounds, including flavonoid glycosides, by gut microbiota.3,4,5 4-Hydroxyphenylacetic acid (100 mg/kg) inhibits seawater instillation-induced increases in TNF-α, IL-1β, and IL-6 levels in lung tissue and white blood cell numbers in bronchoalveolar lavage fluid (BALF) and prevents lung edema in a rat model of acute lung injury.1 It reverses hepatic steatosis in a mouse model of high-fat diet-induced obesity when administered via a subcutaneous implant at a dose of 350 µg/day for two weeks.2 Levels of 4-hydroxyphenylacetic acid are increased and decreased in serum and urine, respectively, in rats fed a high-fat diet.3 Serum levels of 4-hydroxyphenylacetic acid are increased in patients with stage III pancreatic cancer.6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, Z., Xi, R., Zhang, Z., et al. 4-hydroxyphenylacetic acid attenuated inflammation and edema via suppressing HIF-1α in seawater aspiration-induced lung injury in rats. Int. J. Mol. Sci. 15(7), 12861-12884 (2014).

    2. Osborn, L.J., Schultz, K., Massey, W., et al. A gut microbial metabolite of dietary polyphenols reverses obesity-driven hepatic steatosis. Proc. Natl. Acad. Sci. USA 119(48), e2202934119 (2022).

    3. Zeng, Y., Lin, Y., Li, L., et al. Targeted metabolomics for the quantitative measurement of 9 gut microbiota-host co-metabolites in rat serum, urine and feces by liquid chromatography-tandem mass spectrometry. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 1110-1111, 133-143 (2019).

    4. Kim, D.-H., Jung, E.-A., Sohng, I.-S., et al. Intestinal bacterial metabolism of flavonoids and its relation to some biological activities. Arch. Pharm. Res. 21(1), 17-23 (1998).

    5. Chen, H., and Sang, S. Biotransformation of tea polyphenols by gut microbiota. J. Funct. Foods 7, 26-42 (2014).

    6. Nishiumi, S., Shinohara, M., Ikeda, A., et al. Serum metabolomics as a novel diagnostic approach for pancreatic cancer. Metabolomics 6(4), 518–528 (2010).