A minor phase II metabolite of (–)-sitagliptin
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Parent Compound(s)
13252(–)-Sitagliptin (phosphate)
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(–)-Sitagliptin Carbamoyl Glucuronide

Item No. 26629

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[N-[(1R)-3-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-3-oxo-1-[(2,4,5-trifluorophenyl)methyl]propyl]carbamate] β-D-glucopyranuronic acid
CAS Number
940002-59-5
Synonyms
  • (R)-Sitagliptin Carbamoyl Glucuronide
Molecular Formula
C23H23F6N5O9
Formula Weight
627.5
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: soluble
SMILES
FC1=CC(C[C@@H](NC(O[C@@H]2O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]2O)=O)CC(N3CC4=NN=C(C(F)(F)F)N4CC3)=O)=C(F)C=C1F
InChi Code
InChI=1S/C23H23F6N5O9/c24-10-6-12(26)11(25)4-8(10)3-9(30-22(41)43-20-17(38)15(36)16(37)18(42-20)19(39)40)5-14(35)33-1-2-34-13(7-33)31-32-21(34)23(27,28)29/h4,6,9,15-18,20,36-38H,1-3,5,7H2,(H,30,41)(H,39,40)/t9-,15+,16+,17-,18+,20+/m1/s1
InChi Key
GKDZQUQEXZXGMZ-KUVPMCASSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    Cayman Chemical
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    Product Description

    (–)-Sitagliptin carbamoyl glucuronide is a minor phase II metabolite of the dipeptidyl peptidase 4 (DPP-4) inhibitor (–)-sitagliptin (Item No. 13252).1 (–)-Sitagliptin carbamoyl glucuronide is formed by N-carbamoyl glucuronidation and has been found in rat and dog plasma following administration of (–)-sitagliptin.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Beconi, M.G., Reed, J.R., Teffera, Y., et al. Disposition of the dipeptidyl peptidase 4 inhibitor sitagliptin in rats and dogs. Drug Metab. Dispos. 35(4), 525-532 (2007).