A triterpene with diverse biological activities
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Ganoderic Acid A

Item No. 26674

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(25R)-7β,15α-dihydroxy-3,11,23-trioxo-lanost-8-en-26-oic acid
CAS Number
81907-62-2
Molecular Formula
C30H44O7
Formula Weight
516.7
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 1 mg/mlEthanol: 3 mg/ml
λmax
252 nm
SMILES
O=C1CC[C@@]2(C)[C@](C[C@H](O)C([C@@]([C@@H](O)C[C@]3([H])[C@H](C)CC(C[C@@H](C)C(O)=O)=O)(C)[C@]3(C)C4)=C2C4=O)([H])C1(C)C
InChi Code
InChI=1S/C30H44O7/c1-15(10-17(31)11-16(2)26(36)37)18-12-23(35)30(7)25-19(32)13-21-27(3,4)22(34)8-9-28(21,5)24(25)20(33)14-29(18,30)6/h15-16,18-19,21,23,32,35H,8-14H2,1-7H3,(H,36,37)/t15-,16-,18-,19+,21+,23+,28+,29-,30+/m1/s1
InChi Key
DYOKDAQBNHPJFD-JNTBEZBXSA-N
Origin
Fungus/Ganoderma lucidium karst.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $149

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    10 mg

    $224

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    25 mg

    $369

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    50 mg

    $521

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    Product Description

    Ganoderic acid A is a triterpene that has been found in Ganoderma and has diverse biological activities.1,2,3,4 It reduces cell viability, expression of superoxide dismutase 1 (SOD1), SOD2, and SOD3, and production of reactive oxygen species (ROS) in PC3 prostate cancer cells.1 It inhibits LPS-induced activation of NF-κB, release of TNF-α, IL-1β, and IL-6, and mitochondrial activity in primary mouse cortical microglia.2 Ganoderic acid A (20 and 40 mg/kg) reduces lung myeloperoxidase (MPO) activity, neutrophil infiltration, and NF-κB signaling, as well as bronchoalveolar lavage fluid (BALF) levels of TNF-α, IL-1β, and IL-6 in a mouse model of LPS-induced lung injury.3 It also reduces weight gain and hepatic lipid accumulation and improves insulin sensitivity in a mouse model of high-fat diet-induced obesity.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gill, B.S., Kumar, S., and Gill, N. Evaluating anti-oxidant potential of ganoderic acid A in STAT 3 pathway in prostate cancer. Mol. Biol. Rep. 43(12), 1411-1422 (2016).

    2. Chi, B., Wang, S., Bi, S., et al. Effects of ganoderic acid A on lipopolysaccharide-induced proinflammatory cytokine release from primary mouse microglia cultures. Exp. Ther. Med. 15(1), 847-853 (2018).

    3. Wan, B., Li, Y., Sun, S., et al. Ganoderic acid A attenuates lipopolysaccharide-induced lung injury in mice. Biosci. Rep. 39(5), BSR20190301 (2019).

    4. Zhu, J., Jin, J., Ding, J., et al. Ganoderic Acid A improves high fat diet-induced obesity, lipid accumulation and insulin sensitivity through regulating SREBP pathway. Chem. Biol. Interact. 290, 77-87 (2018).