A triterpenoid with diverse biological activities
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Ganoderic Acid B

Item No. 30112

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,7β,25R)-3,7-dihydroxy-11,15,23-trioxo-lanost-8-en-26-oic acid
CAS Number
81907-61-1
Molecular Formula
C30H44O7
Formula Weight
516.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
λmax
255 mn
SMILES
O[C@H]1CC[C@@]2(C)[C@](C[C@H](O)C([C@@](C(C[C@]3([H])[C@H](C)CC(C[C@@H](C)C(O)=O)=O)=O)(C)[C@]3(C)C4)=C2C4=O)([H])C1(C)C
InChi Code
InChI=1S/C30H44O7/c1-15(10-17(31)11-16(2)26(36)37)18-12-23(35)30(7)25-19(32)13-21-27(3,4)22(34)8-9-28(21,5)24(25)20(33)14-29(18,30)6/h15-16,18-19,21-22,32,34H,8-14H2,1-7H3,(H,36,37)/t15-,16-,18-,19+,21+,22+,28+,29-,30+/m1/s1
InChi Key
LWPLEHFGBRFRKI-NBCWKOIPSA-N
Origin
Fungus/Ganoderma lucidum
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    Product Description

    Ganoderic acid B is a triterpenoid that has been found in G. lucidum and has diverse biological activities.1,2,3 It inhibits HIV-1 protease with an IC50 value of 0.17 mM.1 Ganoderic acid B is cytotoxic to HepG2 and Caco-2 cells (IC50s = 0.65 and 0.36 mg/ml, respectively).2 It inhibits acetic acid-induced writhing in mice by 48.3% when administered at a dose of 5 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. El-Mekkawy, S., Meselhy, M.R., Nakamura, N., et al. Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidum. Phytochemistry 49(6), 1651-1657 (1998).

    2. Ruan, W., Lim, A.H.H., Huang, L.G., et al. Extraction optimisation and isolation of triterpenoids from Ganoderma lucidum and their effect on human carcinoma cell growth. Nat. Prod. Res. 28(24), 2264-2272 (2014).

    3. Koyama, K., Imaizumi, T., Akiba, M., et al. Antinociceptive components of Ganoderma lucidum. Planta Med. 63(3), 224-227 (1997).