Pentaacetylquercetin

Pentaacetylquercetin is a pentaacetylated derivative of the flavonoid quercetin (Item No. 10005169) that has diverse biological activities, including antioxidant, anti-inflammatory, and anticancer properties.^1,2,3 It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in vitro (IC₅₀ = 3.74 μg/ml) and inhibits iron(II) chloride-induced lipid peroxidation in rat liver mitochondria (IC₅₀ = 20.2 μg/ml).¹ Pentaacetylquercetin inhibits LPS-induced increases in nitrite (IC₅₀ = 8.7 μM) and PGE₂ (Item No. 14010) production, as well as inducible nitric oxide synthase (iNOS) and COX-2 levels, in RAW 264.7 cells when used at concentrations of 20 and 40 μM.² It also inhibits the growth of HL-60, U937, and SK-MEL-1 cells (IC₅₀s = 38, 25, and 58 μM, respectively).³

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1. Chang, H.-F., and Yang, L.-L. Radical-scavenging and rat liver mitochondria lipid peroxidative inhibitory effects of natural flavonoids from traditional medicinal herbs. J. Med. Plant Res. 6(6), 997-1006 (2012).

2. Chen, Y.-C., Shen, S.-C., Lee, W.-R., et al. Inhibition of nitric oxide synthase inhibitors and lipopolysaccharide induced inducible NOS and cyclooxygenase-2 gene expressions by rutin, quercetin, and quercetin pentaacetate in RAW 264.7 macrophages. J. Cell. Biochem. 82(4), 537-548 (2001).

3. Díaz, J.G., Carmona, A.J., Torres, F., et al. Cytotoxic activities of flavonoid glycoside acetates from Consolida oliveriana. Planta Med. 74(2), 171-174 (2008).