A metabolite of progesterone
Related Products
Parent Compound(s)
15876Progesterone
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Pregnanediol-3-Glucuronide

Item No. 26714

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3α,5β,20S)-20-hydroxypregnan-3-yl, β-D-glucopyranosiduronic acid
CAS Number
1852-49-9
Synonyms
  • Pregnanediol-3α-Glucuronide
  • Pregnanediol 3α-O-β-D-Glucuronide
  • 5β-Pregnane-3α,20α-diol Glucuronide
Molecular Formula
C27H44O8
Formula Weight
496.6
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: 20 mg/mlEthanol: 20 mg/ml
SMILES
C[C@@]12[C@@](CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@]4([C@H](C)O)[H])([H])C[C@H](O[C@]5([H])O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]5O)CC1
InChi Code
InChI=1S/C27H44O8/c1-13(28)17-6-7-18-16-5-4-14-12-15(8-10-26(14,2)19(16)9-11-27(17,18)3)34-25-22(31)20(29)21(30)23(35-25)24(32)33/h13-23,25,28-31H,4-12H2,1-3H3,(H,32,33)/t13-,14+,15+,16-,17+,18-,19-,20-,21-,22+,23-,25+,26-,27+/m0/s1
InChi Key
ZFFFJLDTCLJDHL-JQYCEVDMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $109

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    1 mg

    $207

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    Product Description

    Pregnanediol-3-glucuronide (PDG) is the primary urinary metabolite of the steroid hormone progesterone (Item No. 15876).1 Levels of PDG in the urine correlate to levels of progesterone measured in the serum.1,2 Analysis of urinary PDG has been used to detect ovulatory and anovulatory menstrual cycles in women as well as to assess the fertility of ovulatory cycles.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. O'Connor, K.A., Brindle, E., Holman, D.J., et al. Urinary estrone conjugate and pregnanediol 3-glucuronide enzyme immunoassays for population research. Clin. Chem. 49(7), 1139-1148 (2003).

    2. Munro, C.J., Stabenfeldt, G.H., Cragun, J.R., et al. Relationship of serum estradiol and progesterone concentrations to the excretion profiles of their major urinary metabolites as measured by enzyme immunoassay and radioimmunoassay. Clin. Chem. 37(6), 838-844 (1991).

    3. Kassam, A., Overstreet, J.W., Snow-Harter, C., et al. Identification of anovulation and transient luteal function using a urinary pregnanediol-3-glucuronide ratio algorithm. Environ. Health Perspect. 104(4), 408-413 (1996).

    4. Blackwell, L.F., Cooke, D.G., and Brown, S. The use of estrone-3-glucuronide and pregnanediol-3-Glucuronide Excretion Rates to Navigate the Continuum of Ovarian Activity. Front. Public Health 6:153, (2018).