An endogenous hormone and hormone precursor
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Progesterone

Item No. 15876

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
pregn-4-ene-3,20-dione
CAS Number
57-83-0
Synonyms
  • Cyclogest
  • NSC 9704
  • NSC 64377
Molecular Formula
C21H30O2
Formula Weight
314.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: 1 mg/mlEthanol: 1 mg/mlMethanol: 1 mg/ml
λmax
239 nm
SMILES
C[C@@]12[C@](CC[C@@H]2C(C)=O)([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])CC1)=O
InChi Code
InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
InChi Key
RJKFOVLPORLFTN-LEKSSAKUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

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    Product Description

    Progesterone, along with pregnenolone, is the biosynthetic precursor of all other steroid hormones. Progesterone is synthesized from cholesterol by the sequential action of desmolase in the mitochondria, which produces pregnenolone, followed by Δ4,5-isomerase in the outer mitochondrial membrane and smooth endoplasmic reticulum of steroid-secreting cells.1 Progesterone activates the human progesterone receptor with an EC50 value of 0.5 nM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Erickson, G.F. The ovary: Basic principles and concepts. A. Physiology. Endocrinology and Metabolism 973-1015 (1995).

    2. Pedram, B., van Oeveren, A., Mais, D.E., et al. A tissue-selective nonsteroidal progesterone receptor modulator: 7,9-Difluoro-5-(3-methylcyclohex-2-enyl)-2,2,4-trimethyl-1,2-dihydrochromeno[3,4-f]quinoline. J. Med. Chem. 51(13), 3696-3699 (2008).