An internal standard for the quantification of flibanserin
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Unlabeled Version(s)
19203Flibanserin
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Flibanserin-d4 (hydrochloride)

Item No. 26779

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,3-dihydro-1-[2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl-1,1,2,2-d4]-2H-benzimidazol-2-one, monohydrochloride
CAS Number
2748630-46-6
Molecular Formula
C20H17D4F3N4O • HCl
Formula Weight
430.9
Purity
≥99% deuterated forms (d1-d4)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: slightly solubleMethanol: slightly soluble
SMILES
O=C1N(C([2H])([2H])C([2H])([2H])N2CCN(C3=CC(C(F)(F)F)=CC=C3)CC2)C4=CC=CC=C4N1.Cl
InChi Code
InChI=1S/C20H21F3N4O.ClH/c21-20(22,23)15-4-3-5-16(14-15)26-11-8-25(9-12-26)10-13-27-18-7-2-1-6-17(18)24-19(27)28;/h1-7,14H,8-13H2,(H,24,28);1H/i10D2,13D2;
InChi Key
XGAGFLQFMFCIHZ-BMJFOILFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    Product Description

    Flibanserin-d4 is intended for use as an internal standard for the quantification of flibanserin (Item No. 19203) by GC- or LC-MS. Flibanserin is a full agonist of the serotonin 5-HT1A receptor and an antagonist of 5-HT2A (Kis = 1 and 49 nM, respectively).1 It also binds to dopamine D4 receptors with Ki values ranging from 4-24 nM, but demonstrates no affinity for the other 5-HT subtypes or other neurotransmitter receptors.1 In vitro, flibanserin has been shown to reduce forskolin-stimulated cAMP formation in cells and rat tissues and to antagonize the accumulation of phosphatidyl inositol turnover induced by 5-HT in the mouse cortex.1 At 10 mg/kg, flibanserin can reduce serotonin in the prefrontal cortex and dorsal raphe of conscious rats while increasing extracellular noradrenaline and dopamine.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Invernizzi, R.W., Sacchetti, G., Parini, S., et al. Flibanserin, a potential antidepressant drug, lowers 5-HT and raises dopamine and noradrenaline in the rat prefrontal cortex dialysate: Role of 5-HT1A receptors. Br. J. Pharmacol. 139(7), 1281-1288 (2003).