A monoacylglycerol
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1-Oleoyl Glycerol

Item No. 26793

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9Z-octadecenoic acid, 2,3-dihydroxypropyl ester
CAS Number
111-03-5
Synonyms
  • 18:1-MG
  • MG(18:1)
  • 1-Monoolein
  • 1-Oleoyl-rac-glycerol
Molecular Formula
C21H40O4
Formula Weight
356.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: 50 mg/ml
SMILES
O=C(CCCCCCC/C=C\CCCCCCCC)OCC(O)CO
InChi Code
InChI=1S/C21H40O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(24)25-19-20(23)18-22/h9-10,20,22-23H,2-8,11-19H2,1H3/b10-9-
InChi Key
RZRNAYUHWVFMIP-KTKRTIGZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 mg

    $81

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    500 mg

    $128

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    1 g

    $222

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    Cayman Chemical
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    Product Description

    1-Oleoyl glycerol is a monoacylglycerol containing oleic acid (Item No. 90260) at the sn-1 position. 1-Oleoyl glycerol (10%), in a formulation with cyclosporin A (Item No. 12088) in propylene glycol, enhances diffusion of cyclosporin A from the donor compartment of a Franz diffusion cell into the stratum corneum, epidermis, and dermis of porcine ear skin, as well as through the skin to the receptor compartment.1 Mixed micellar systems containing 1-oleoyl glycerol and bile salts increase the apparent permeability coefficient (Papp) and absorption rate of amphotericin B (Item No. 11636) in perfused rat intestine in vivo.2 Lipid nanoparticles (LNPs) containing 1-oleoyl-glycerol and encapsulating various mRNAs exhibit enhanced pulmonary delivery via intranasal administration and targeted spleen delivery via intravenous administration in mice compared with LNPs containing DSPC.3 Formulations containing 1-oleoyl glycerol have been used as emulsifying agents, food additives, and absorption enhancers.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lopes, L.B., Collett, J.H., and Bentley, M.V.L.B. Topical delivery of cyclosporin A: An in vitro study using monoolein as a penetration enhancer. Eur. J. Pharm. Biopharm. 60(1), 25-30 (2005).

    2. Dangi, J.S., Vyas, S.P., and Dixit, V.K. Effect of various lipid-bile salt mixed micelles on the intestinal absorption of amphotericin-B in rat. Drug Dev. Ind. Pharm. 24(7), 631-635 (1998).

    3. Martinez, N., Yu, H., Iscaro, J., et al. Structure-function correlation of clinically inspired lipid nanoparticles for lung and spleen targeted mRNA delivery. Adv. Healthc. Mater. 26, e03612 (2025).