A diterpene with diverse biological activities
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Tanshinone I

Item No. 26852

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,6-dimethyl-phenanthro[1,2-b]furan-10,11-dione
CAS Number
568-73-0
Synonyms
  • Tanshinone A
Molecular Formula
C18H12O3
Formula Weight
276.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 0.3 mg/mlEthanol: 0.1 mg/ml
λmax
245, 420 nm
SMILES
O=C(C1=C2C(C(C)=CC=C2)=CC=C1C3=C4C(C)=CO3)C4=O
InChi Code
InChI=1S/C18H12O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-8H,1-2H3
InChi Key
AIGAZQPHXLWMOJ-UHFFFAOYSA-N
Origin
Plant/Salviae Miltiorrhizae Radix et Rhizoma
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $63

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    10 mg

    $118

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    25 mg

    $274

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    50 mg

    $481

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    Product Description

    Tanshinone I is a diterpene that has been found in S. miltiorrhiza and has diverse biological activities, including anticancer, antidiabetic, and neuroprotective properties.1,2,3,4 It inhibits proliferation in a variety of cancer cell lines, including KB/VCR, MCF-7/ADR, and K562/A02 multidrug resistance cell lines.2 It inhibits topoisomerase I- and topoisomerase II-mediated supercoiled DNA relaxation activity when used at concentrations of 200 and 25 µM, respectively. Tanshinone I also inhibits proliferation of H358-IR and H157-IR radioresistant lung cancer cells (IC50s = 10.87 and 6.1 µM, respectively) and sensitizes them to radiation.3 It reduces plasma levels of total cholesterol, triglycerides, LDL, and nonesterified fatty acids and decreases blood glucose levels in a rat model of type 2 diabetes induced by streptozotocin (Item No. 13104) and a high-fat diet.5 Tanshinone I reduces the LPS-induced expression of TNF-α, IL-1β, and IL-6 in microglia in vitro.4 It is neuroprotective in a mouse model of Parkinson’s disease induced by MPTP, preventing dopaminergic cell death in the striatum and improving motor function when administered at a dose of 10 mg/kg per day for two weeks.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yang, L., Ding, G., Lin, H., et al. Transcriptome analysis of medicinal plant Salvia miltiorrhiza and identification of genes related to tanshinone biosynthesis. PLoS One 8(11), e80464 (2013).

    2. Tian, Q.-T., Ding, C.-Y., Song, S.-S., et al. New tanshinone I derivatives S222 and S439 similarly inhibit topoisomerase I/II but reveal different p53-dependency in inducing G2/M arrest and apoptosis. Biochem. Pharmacol. 156, 255-264 (2018).

    3. Yan, Y., Su, W., Zeng, S., et al. Effect and mechanism of tanshinone I on the radiosensitivity of lung cancer cells. Mol. Pharm. 15(11), 4843-4853 (2018).

    4. Wang, S., Jing, H., Yang, H., et al. Tanshinone I selectively suppresses pro-inflammatory genes expression in activated microglia and prevents nigrostriatal dopaminergic neurodegeneration in a mouse model of Parkinson’s disease. J. Ethnaopharmacol. 164, 247-255 (2015).

    5. Wei, Y., Gao, J., Qin, L., et al. Tanshinone I alleviates insulin resistance in type 2 diabetes mellitus rats through IRS-1 pathway. Biomed. Pharmacother. 93, 352-356 (2017).