An anticoagulant rodenticide
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Bromadiolone

Item No. 26854

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[3-(4'-bromo[1,1'-biphenyl]-4-yl)-3-hydroxy-1-phenylpropyl]-4-hydroxy-2H-1-benzopyran-2-one
CAS Number
28772-56-7
Synonyms
  • Bromatrol
  • Broprodifacoum
Molecular Formula
C30H23BrO4
Formula Weight
527.4
Purity
≥95% (mixture of diastereomers)
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
λmax
266 nm
SMILES
BrC1=CC=C(C2=CC=C(C(O)CC(C3=CC=CC=C3)C4=C(O)C5=C(C=CC=C5)OC4=O)C=C2)C=C1
InChi Code
InChI=1S/C30H23BrO4/c31-23-16-14-20(15-17-23)19-10-12-22(13-11-19)26(32)18-25(21-6-2-1-3-7-21)28-29(33)24-8-4-5-9-27(24)35-30(28)34/h1-17,25-26,32-33H,18H2
InChi Key
OWNRRUFOJXFKCU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    50 mg

    $41

    Add

    100 mg

    $75

    Add
    Cayman Chemical
    Visit Our Environmental Toxicology Resource Center

    Explore additional resources to study natural toxins, pollutants including PFAS and 6-PPD-Q, and their biological effects.

    ENVIRONMENTAL TOXICOLOGY TOOLS & SERVICES
    Product Description

    Bromadiolone is a second generation anticoagulant rodenticide and 4-hydroxycoumarin derivative.1,2 It is an inhibitor of vitamin K epoxide reductase (VKOR) that inhibits blood clotting. It inhibits human VKOR complex subunit 1 (VKORC1) with an IC50 value of 1.6 nM in a cell-based assay.3 Bromadiolone is toxic to rodents, including mice (LD50 = 1.75 mg/kg) and rats (LD50s = 1.05 and 1.83 mg/kg for males and females, respectively).4,5 It does not significantly affect breeding performance in mice when administered at a dose of up to 70% of the LD50 value.6 Resistance to bromadiolone is conferred by mutations to the VKOR gene, Vkorc1.7 Formulations containing bromadiolone have been used in the control of rodent pest populations.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Watt, B.E., Proudfoot, A.T., Bradberry, S.M., et al. Anticoagulant rodenticides. Toxicol. Rev. 24(4), 259-269 (2005).

    2. Misenheimer, T.M., Lund, M., Baker, A.E.M., et al. Biochemical basis of warfarin and bromadiolone resistance in the house mouse, Mus musculus domesticus. Biochem. Pharmacol. 47(4), 673-678 (1994).

    3. Czogalla, K.J., Liphardt, K., Höning, K., et al. VKORC1 and VKORC1L1 have distinctly different oral anticoagulant dose-response characteristics and binding sites. Blood Adv. 2(6), 691-702 (2018).

    4. Vandenbroucke, V., Bousquet-Melou, A., De Backer, P., et al. Pharmacokinetics of eight anticoagulant rodenticides in mice after single oral administration. J. Vet. Pharmacol. Ther. 31(5), 437-445 (2008).

    5. Garg, N., and Singla, N. Toxicity of second generation anticoagulant bromadiolone against Rattus Rattus: individual and sex specific variations. Cibtech J. Zoo. 3(2), 43-48 (2014).

    6. Twigg, L.E., and Kay, B.J. The effect of sub-lethal doses of bromadiolone on the breeding performance of house mice (Mus domesticus). Comp. Biochem. Physiol. 110(1), 77-82 (1995).

    7. Pelz, H.-J., Rost, S., Hünerberg, M., et al. The genetic basis of resistance to anticoagulants in rodents. Genetics 170(4), 1839-1847 (2005).