An antispasmodic agent
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Biochemicals

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Neuroscience
Pain Research

Alverine (citrate)

Item No. 26892

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-ethyl-N-(3-phenylpropyl)-benzenepropanamine, mono-2-hydroxy-1,2,3-propanetricarboxylate
CAS Number
5560-59-8
Synonyms
  • NSC 35459
Molecular Formula
C20H27N • C6H8O7
Formula Weight
473.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: slightly solublePBS (pH 7.2): 1 mg/ml
SMILES
CCN(CCCC1=CC=CC=C1)CCCC2=CC=CC=C2.OC(CC(C(O)=O)(O)CC(O)=O)=O
InChi Code
InChI=1S/C20H27N.C6H8O7/c1-2-21(17-9-15-19-11-5-3-6-12-19)18-10-16-20-13-7-4-8-14-20;7-3(8)1-6(13,5(11)12)2-4(9)10/h3-8,11-14H,2,9-10,15-18H2,1H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
InChi Key
RYHCACJBKCOBTJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
4°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 g

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    Product Description

    Alverine is an antispasmodic agent.1 It suppresses contractions induced by potassium or acetylcholine (ACh), but increases spontaneous contractions, in isolated guinea pig detrusor smooth muscle. Alverine blocks spontaneous and vagal-stimulated colonic motility in rabbits.2 Alverine (75 μg/animal) reduces the number of abdominal contractions induced by 5-hydroxy-L-tryptophan (5-HTP; Item No. 20539) or high volume (1.6 ml) rectal distension in rats.3 Formulations containing alverine have been used in the treatment of functional gut disorders.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hayase, M., Hashitani, H., Suzuki, H., et al. Evolving mechanisms of action of alverine citrate on phasic smooth muscles. Br. J. Pharmacol. 152(8), 1228-1238 (2007).

    2. Bouvier, M., Grimaud, J.C., Abysique, A., et al. Effects of alverine on the spontaneous electrical activity and nervous control of the proximal colon of the rabbit. Gastroenterol. Clin. Biol. 16(4), 334-338 (1992).

    3. Coelho, A.-M., Jacob, L., Fioramonti, J., et al. Rectal antinociceptive properties of alverine citrate are linked to antagonism at the 5-HT1A receptor subtype. J. Pharm. Pharmacol. 53(10), 1419-1426 (2001).