A short-chain sphingolipid
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Sphingosine (d12:1)

Item No. 26893

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2S-amino-4E-dodecene-1,3R-diol
CAS Number
128427-86-1
Synonyms
  • D-erythro-Sphingosine C12
Molecular Formula
C12H25NO2
Formula Weight
215.3
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mLDMSO: 2 mg/mlEthanol: miscible
SMILES
OC[C@H](N)[C@H](O)/C=C/CCCCCCC
InChi Code
InChI=1S/C12H25NO2/c1-2-3-4-5-6-7-8-9-12(15)11(13)10-14/h8-9,11-12,14-15H,2-7,10,13H2,1H3/b9-8+/t11-,12+/m0/s1
InChi Key
NCNKWPUJUUMFNR-VDTGWRSZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $70

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    1 mg

    $129

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    5 mg

    $436

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    Product Description

    Sphingosine (d12:1) is a short-chain sphingolipid.1,2 It decreases serine palmitoyltransferase activity in primary cultured mouse cerebellar cells in a concentration-dependent manner.1 Sphingosine (d12:1) (0.5-50 μM) decreases production of sphingosine (d18:1) (Item No. 10007907), lactosylceramide (Item Nos. 27197 | 16983), galactosylceramide (Item No. 24322), and a variety of gangliosides in mouse cerebellar granule cells.2 [Matreya, LLC. Catalog No. 1838]

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mandon, E.C., van Echten, G., Birk, R., et al. Sphingolipid biosynthesis in cultured neurons: Down-regulation of serine palmitoyltransferase by sphingoid bases. Eur. J. Biochem. 198(3), 667-674 (1991).

    2. van Echten, G., Birk, R., Brenner-Weiss, G., et al. Modulation of sphingolipid biosynthesis in primary cultured neurons by long chain bases. The Journal of Biological Chemisty 265(16), 9333-9339 (1990).