Roridin E

Roridin E is a macrocyclic trichothecene mycotoxin that has been found in M. verrucaria.¹ It inhibits the receptor tyrosine kinases FGFR3, IGF-1R, PDGFRβ, and TrkB (IC₅₀s = 0.4, 0.4, 1.4, and 1 μM, respectively).² Roridin E induces cytotoxicity in multiple breast cancer cell lines (IC₅₀s = 0.02-0.05 nM) and inhibits proliferation in a panel of additional cancer cell lines (IC₅₀s = <0.01 μM).^3,2 It also inhibits proliferation of the mammalian H4TG, MDCK, NIH3T3, and KA31T cell lines (IC₅₀s = 1.74-7.68 nM).⁴ Roridin E inhibits the growth of P. falciparum (EC₅₀ = 0.15 ng/ml), induces phytotoxicity in duckweed and kudzu, and is toxic to mice (LD₅₀ = 10 mg/kg, i.p.).^1,5 Roridin E is also produced by the plant B. coridifolia, which is associated with livestock poisoning in South America.⁵

WARNING This product is not for human or veterinary use.

1. Isaka, M., Punya, J., Lertwerawat, Y., et al. Antimalarial activity of macrocyclic trichothecenes isolated from the fungus Myrothecium verrucaria. J. Nat. Prod. 62(2), 329-331 (1999).

2. Li, Y., Liu, D., Cheng, Z., et al. Cytotoxic trichothecene-type sesquiterpenes from the sponge-derived fungus Stachybotrys chartarum with tyrosine kinase inhibition. RSC Adv. 7(12), 7259-7267 (2017).

3. Lee, S.R., Seok, S., Ryoo, R., et al. Macrocyclic trichothecene mycotoxins from a deadly poisonous mushroom, Podostroma cornu-damae. J. Nat. Prod. 82(1), 122-128 (2019).

4. Abbas, H.K., Johnson, B.B., Shier, W.T., et al. Phytotoxicity and mammalian cytotoxicity of macrocyclic trichothecene mycotoxins from Myrothecium verrucaria. Phytochemistry 59(3), 309-313 (2002).

5. Habermehl, G.G., Busam, L., Heydel, P., et al. Macrocyclic trichothecenes: Cause of livestock poisoning by the Brazilian plant Baccharis coridifolia. Toxicon. 23(5), 731-745 (1985).