A DNA alkylating agent
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Isomer(s)
33499Fervenulin
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K-TMZ

Item No. 27022

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-acetyl-3-methyl-imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one
CAS Number
2269482-26-8
Molecular Formula
C7H7N5O2
Formula Weight
193.2
Purity
≥95%
Formulation (Request formulation change)
A 1 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 10 mg/mlEthanol:PBS (pH 7.2) (1:2): 0.3 mg/ml
λmax
213, 331 nm
SMILES
CN(N=N1)C(N2C1=C(C(C)=O)N=C2)=O
InChi Code
InChI=1S/C7H7N5O2/c1-4(13)5-6-9-10-11(2)7(14)12(6)3-8-5/h3H,1-2H3
InChi Key
QXYCTGXCOQXVRU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $117

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    5 mg

    $288

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    10 mg

    $456

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    Cayman Chemical
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    Product Description

    K-TMZ is a DNA alkylating agent.1 It increases the concentration of O6-methylated deoxyguanosine in U87 glioblastoma multiforme (GBM) cells in a concentration-dependent manner. K-TMZ reduces cell viability of GBM cell lines lacking (IC50s = 18-44 μM) or expressing O6-methylguanine DNA methyltransferase (MGMT; IC50s = 115-240 μM). K-TMZ can cross the blood-brain barrier and increases survival in a Br23c mouse xenograft model of GBM when administered at a dose of 14.9 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Svec, R.L., Furiassi, L., Skibinski, C.G., et al. Tunable stability of imidazotetrazines leads to a potent compound for glioblastoma. ACS Chem. Biol. 13(11), 3206-3216 (2018).