An internal standard for the quantification of β-muricholic acid
Related Products
Isomer(s)
27037ω-Muricholic Acid-d4
Unlabeled Version(s)
20287β-Muricholic Acid
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

β-Muricholic Acid-d4

Item No. 27035

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5β)-3α,6β,7β-trihydroxy-cholan-2,2,4,4-d4-24-oic acid
Synonyms
  • 5β-Cholanic Acid-3α,6β,7β-triol-d4
  • β-MCA-d4
Molecular Formula
C24H36D4O5
Formula Weight
412.6
Purity
≥99% deuterated forms (d1-d4)
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:1): 0.5 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/ml
SMILES
OC(CC[C@@H](C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@@H](O)[C@@H](O)[C@]4([H])C([2H])([2H])[C@H](O)C([2H])([2H])C[C@]4(C)[C@@]3([H])CC[C@@]21C)=O
InChi Code
InChI=1S/C24H40O5/c1-13(4-7-19(26)27)15-5-6-16-20-17(9-11-23(15,16)2)24(3)10-8-14(25)12-18(24)21(28)22(20)29/h13-18,20-22,25,28-29H,4-12H2,1-3H3,(H,26,27)/t13-,14-,15-,16+,17+,18+,20+,21+,22-,23-,24-/m1/s1/i8D2,12D2
InChi Key
DKPMWHFRUGMUKF-APBBRSFGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $267

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    β-Muricholic acid-d4 (β-MCA-d4) is intended for use as an internal standard for the quantification of β-muricholic acid (Item No. 20287) by GC- or LC-MS. β-MCA is a murine-specific primary bile acid.1,2 Dietary administration of β-MCA reduces HMG-CoA reductase activity in liver microsomes from mice fed a high cholesterol and cholic acid diet.3 Dietary administration of β-MCA also dissolves 100% of gallstones in a gallstone-susceptible mouse model of diet-induced cholesterol gallstones.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Eyssen, H.J., Parmentier, G.G., and Mertens, J.A. Sulfate bile acids in germ-free and conventional mice. Eur. J. Biochem. 66(3), 507-514 (1976).

    2. Wahlström, A., Sayin, S.I., Marschall, H.-I., et al. Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism. Cell Metab. 24(1), 41-50 (2016).

    3. Fujino, Y., Nakayama, K., Yoshimura, K., et al. Suppression of hepatic HMG-CoA reductase activity by β-muricholic acid in mice fed a diet containing cholesterol and cholic acid. Jpn. J. Pharmacol. 46(4), 421-423 (1988).

    4. Wang, D.Q.-H., and Tazuma, S. Effect of β-muricholic acid on the prevention and dissolution of cholesterol gallstones in C57L/J mice. J. Lipid. Res. 43(11), 1960-1968 (2002).