An internal standard for the quantification of taurohyocholic acid
Related Products
Unlabeled Version(s)
22669Taurohyocholic Acid (sodium salt)
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Taurohyocholic Acid-d4 (sodium salt)

Item No. 27038

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[(3α,5β,6α,7α)-3,6,7-trihydroxy-24-oxocholan-24-yl-2,2,4,4-d4]amino]-ethanesulfonic acid, monosodium salt
Synonyms
  • Taurine Hyocholate-d4
  • Tauro-γ-muricholic Acid-d4
  • Taurohyocholate-d4
  • THCA-d4
Molecular Formula
C26H40D4NO7S • Na
Formula Weight
541.7
Purity
≥99% deuterated forms (d1-d4)
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:1): 0.5 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/ml
SMILES
O[C@@H]1C([2H])([2H])C[C@@]2(C)[C@@]([C@@H](O)[C@@H](O)[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCC(NCCS([O-])(=O)=O)=O)([H])C1([2H])[2H].[Na+]
InChi Code
InChI=1S/C26H45NO7S.Na/c1-15(4-7-21(29)27-12-13-35(32,33)34)17-5-6-18-22-19(9-11-25(17,18)2)26(3)10-8-16(28)14-20(26)23(30)24(22)31;/h15-20,22-24,28,30-31H,4-14H2,1-3H3,(H,27,29)(H,32,33,34);/q;+1/p-1/t15-,16-,17-,18+,19+,20+,22+,23-,24+,25-,26-;/m1./s1/i8D2,14D2;
InChi Key
NYXROOLWUZIWRB-KOMZIBPTSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $268

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    Taurohyocholic acid-d4 (THCA-d4) is intended for use as an internal standard for the quantification of THCA (Item No. 22669) by GC- or LC-MS. THCA is a taurine-conjugated form of the porcine-specific primary bile acid hyocholic acid (Item No. 20293).1 THCA inhibits precipitation of cholesterol crystals by stabilizing cholesterol in the liquid-crystalline phase.2 It prevents cholestasis and cellular necrosis induced by taurolithocholic acid (Item No. 17275) in isolated rat liver.3 THCA levels are increased in the urine of patients with hepatitis B-induced cirrhosis.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wahlström, A., Sayin, S.I., Marschall, H.-I., et al. Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism. Cell Metab. 24(1), 41-50 (2016).

    2. Juste, C., Catala, I., Henry, R., et al. Influence of bile salt molecular species on cholesterol crystallization from supersaturated model biles. Biochim. Biophys. Acta 1254(1), 89-97 (1995).

    3. Scholmerich, J., Kitamura, S., Baumgartner, U., et al. Taurohyocholate, taurocholate, and tauroursodeoxycholate but not tauroursocholate and taurodehydrocholate counteract effects of taurolithocholate in rat liver. Res. Exp. Med. (Berl.) 190(2), 121-129 (1990).

    4. Wang, X., Xie, G., Zhao, A., et al. Serum bile acids are associated with pathological progression of hepatitis B-induced cirrhosis. J. Proteome Res. 15(4), 1126-1134 (2016).