A primary bile acid in pigs and other mammals
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Hyocholic Acid

Item No. 20293

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5β)-3α,6α,7α-trihydroxy-cholan-24-oic acid
CAS Number
547-75-1
Synonyms
  • HCA
  • γ-MCA
  • γ-Muricholic Acid
Molecular Formula
C24H40O5
Formula Weight
408.6
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/ml
λmax
210 nm
SMILES
C[C@H](CCC(O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@H](O)[C@H](O)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
InChi Code
InChI=1S/C24H40O5/c1-13(4-7-19(26)27)15-5-6-16-20-17(9-11-23(15,16)2)24(3)10-8-14(25)12-18(24)21(28)22(20)29/h13-18,20-22,25,28-29H,4-12H2,1-3H3,(H,26,27)/t13-,14-,15-,16+,17+,18+,20+,21-,22+,23-,24-/m1/s1
InChi Key
DKPMWHFRUGMUKF-KWXDGCAGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    Product Description

    Hyocholic acid is a primary bile acid in pigs and other mammals.1 It has also been found in urine samples from patients with cholestasis.2 Hyocholic acid is converted by gut microflora primarily to taurohyocholate and, to a lesser extent, taurocholic acid (Item No. 16215) and tauro-β-muricholic acid (Item No. 20289) in mice.3 Hyocholic acid has low toxicity against human hepatoma HepG2 cells.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lundell, K., and Wikvall, K. Species-specific and age-dependent bile acid composition: Aspects on CYP8B and CYP4A subfamilies in bile acid biosynthesis. Curr. Drug Metab. 9(4), 323-331 (2008).

    2. van Berge Henegouwen, G.P., Brandt, K.H., Eyssen, H., et al. Sulphated and unsulphated bile acids in serum, bile, and urine of patients with cholestasis. Gut 17(11), 861-869 (1976).

    3. Wang, D.Q.-H., Tazuma, S., Cohen, D.E., et al. Feeding natural hydrophilic bile acids inhibits intestinal cholesterol absorption: Studies in the gallstone-susceptible mouse. Am. J. Physiol Gastrointest. Liver Physiol. 285(3), G494-G502 (2003).

    4. Perreault, M., Bialek, A., Trottier, J., et al. Role of glucuronidation for hepatic detoxification and urinary elimination of toxic bile acids during biliary obstruction. PLoS One 8(11), e80994 (2013).