A fluorescently tagged peptide
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5-FAM-Amyloid-β (1-28) Peptide (human) (trifluoroacetate salt)

Item No. 27108

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Molecular Formula
C166H219N41O52 • XCF3COOH
Formula Weight
3620.8
Purity
≥95%
Emission
518 nm
Excitation
492 nm
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Formic Acid: 1 mg/ml
SMILES
[H]N(C(C1=CC(C(O)=O)=C(C2=C(C=C3)C(OC4=C2C=CC(O)=C4)=CC3=O)C=C1)=O)[C@@H](CC(O)=O)C(N[C@@H](C)C(N[C@H](C(N[C@@H](CC5=CC=CC=C5)C(N[C@H](C(N[C@@H](CC6=CN=CN6)C(N[C@@H](CC(O)=O)C(N[C@H](C(NCC(N[C@@H](CC7=CC=C(C=C7)O)C(N[C@H](C(N[C@H](C(N[C@@H](CC8=CN=CN8)C(N[C@@H](CC9=CN=CN9)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC%10=CC=CC=C%10)C(N[C@@H](CC%11=CC=CC=C%11)C(N[C@@H](C)C(N[C@H](C(N[C@@H](CC(O)=O)C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CCCCN)=O)CC(N)=O)=O)CO)=O)=O)C(C)C)=O)=O)CCC(O)=O)=O)=O)=O)=O)C(C)C)=O)CC(C)C)=O)CCCCN)=O)CCC(N)=O)=O)=O)=O)C(C)C)=O)CCC(O)=O)=O)=O)=O)CO)=O)=O)=O)CCCNC(N)=N)=O)=O)CCC(O)=O)=O)=O
InChi Code
InChI=1S/C166H219N41O52/c1-80(2)55-108(158(249)207-137(83(7)8)162(253)202-112(58-88-29-18-13-19-30-88)152(243)196-110(56-86-25-14-11-15-26-86)148(239)182-84(9)138(229)187-105(46-50-129(219)220)146(237)200-119(69-133(227)228)159(250)205-135(81(3)4)161(252)178-74-127(216)185-121(76-209)160(251)199-116(66-125(170)214)156(247)192-107(165(257)258)32-21-23-53-168)194-142(233)101(31-20-22-52-167)188-144(235)103(44-48-124(169)213)190-153(244)113(61-91-70-173-77-179-91)198-155(246)115(63-93-72-175-79-181-93)203-163(254)136(82(5)6)206-147(238)106(47-51-130(221)222)191-150(241)109(59-89-34-37-94(210)38-35-89)184-126(215)73-177-141(232)120(75-208)204-157(248)118(68-132(225)226)201-154(245)114(62-92-71-174-78-180-92)197-143(234)102(33-24-54-176-166(171)172)189-151(242)111(57-87-27-16-12-17-28-87)195-145(236)104(45-49-128(217)218)186-139(230)85(10)183-149(240)117(67-131(223)224)193-140(231)90-36-41-97(100(60-90)164(255)256)134-98-42-39-95(211)64-122(98)259-123-65-96(212)40-43-99(123)134/h11-19,25-30,34-43,60,64-65,70-72,77-85,101-121,135-137,208-211H,20-24,31-33,44-59,61-63,66-69,73-76,167-168H2,1-10H3,(H2,169,213)(H2,170,214)(H,173,179)(H,174,180)(H,175,181)(H,177,232)(H,178,252)(H,182,239)(H,183,240)(H,184,215)(H,185,216)(H,186,230)(H,187,229)(H,188,235)(H,189,242)(H,190,244)(H,191,241)(H,192,247)(H,193,231)(H,194,233)(H,195,236)(H,196,243)(H,197,234)(H,198,246)(H,199,251)(H,200,237)(H,201,245)(H,202,253)(H,203,254)(H,204,248)(H,205,250)(H,206,238)(H,207,249)(H,217,218)(H,219,220)(H,221,222)(H,223,224)(H,225,226)(H,227,228)(H,255,256)(H,257,258)(H4,171,172,176)/t84-,85-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,135-,136-,137-/m0/s1
InChi Key
WLIZODMZKKZUAA-ABVAVDJMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 µg

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    Product Description

    5-FAM-Amyloid-β (1-28) peptide is a fluorescently labeled peptide. Amyloid-β (1-28) (Aβ28) is a synthetic peptide that lacks 14 C-terminal amino acids and is more soluble than Aβ42.1 Aβ28 forms fibrils and plaques in vitro that are similar to those formed by Aβ42 and induces learning deficits in a passive avoidance task in rats.2,3,4 5-FAM-Amyloid-β (1-28) is a labeled form of Aβ28 containing 5-carboxyfluorescein (5-FAM; Item No. 19581), which displays excitation/emission maxima of 492/518 nm, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Syme, C.D., Nadal, R.C., Rigby, S.E., et al. Copper binding to the amyloid-beta (Aβ) peptide associated with Alzheimer’s disease. Folding, coordination geometry, pH dependence, stoichiometry, and affinity of Aβ(1-28): Insights from a range of complementary spectroscopic techniques. The Journal of Biological Chemisty 279(18), 18169-18177 (2004).

    2. Kirschner, D.A., Inouye, H., Duffy, L.K., et al. Synthetic peptide homologous to β protein from Alzheimer disease forms amyloid-like fibrils in vitro. Proc. Natl. Acad. Sci. USA 84(19), 6953-6957 (1987).

    3. Burdick, D., Soreghan, B., Kwon, M., et al. Assembly and aggregation properties of synthetic Alzheimer’s A4/β amyloid peptide analogs. The Journal of Biological Chemisty 267(1), 546-554 (1992).

    4. Alvarez, X.A., Miguel-Hidalgo, J.J., Fernández-Novoa, L., et al. Intrahippocampal injections of the beta-amyloid 1-28 fragment induces behavioral deficits in rats. Methods Find. Exp. Clin. Pharmacol. 19(7), 471-479 (1997).