A biotinylated amyloid-β peptide
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Biotin-Amyloid-β (1-28) Peptide (human) (trifluoroacetate salt)

Item No. 27109

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-α-aspartyl-L-alanyl-L-α-glutamyl-L-phenylalanyl-L-arginyl-L-histidyl-L-α-aspartyl-L-serylglycyl-L-tyrosyl-L-α-glutamyl-L-valyl-L-histidyl-L-histidyl-L-glutaminyl-L-lysyl-L-leucyl-L-valyl-L-phenylalanyl-L-phenylalanyl-L-alanyl-L-α-glutamyl-L-α-aspartyl-L-valylglycyl-L-seryl-L-asparaginyl-L-lysine, trifluoroacetate salt
Synonyms
  • Biotin-Aβ (1-28)
  • Biotin-Aβ28
Molecular Formula
C155H223N43O48S • XCF3COOH
Formula Weight
3488.8
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
[H]N(C(CCCC[C@@H]1SC[C@@](N2)([H])[C@]1([H])NC2=O)=O)[C@@H](CC(O)=O)C(N[C@@H](C)C(N[C@H](C(N[C@@H](CC3=CC=CC=C3)C(N[C@H](C(N[C@@H](CC4=CN=CN4)C(N[C@@H](CC(O)=O)C(N[C@H](C(NCC(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@H](C(N[C@H](C(N[C@@H](CC6=CN=CN6)C(N[C@@H](CC7=CN=CN7)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC8=CC=CC=C8)C(N[C@@H](CC9=CC=CC=C9)C(N[C@@H](C)C(N[C@H](C(N[C@@H](CC(O)=O)C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CCCCN)=O)CC(N)=O)=O)CO)=O)=O)C(C)C)=O)=O)CCC(O)=O)=O)=O)=O)=O)C(C)C)=O)CC(C)C)=O)CCCCN)=O)CCC(N)=O)=O)=O)=O)C(C)C)=O)CCC(O)=O)=O)=O)=O)CO)=O)=O)=O)CCCNC(N)=N)=O)=O)CCC(O)=O)=O)=O
InChi Code
InChI=1S/C155H223N43O48S/c1-76(2)53-97(147(238)197-126(79(7)8)151(242)191-101(56-84-31-18-13-19-32-84)141(232)185-99(54-82-27-14-11-15-28-82)137(228)171-80(9)128(219)177-94(44-48-119(209)210)135(226)189-108(64-123(217)218)148(239)195-124(77(3)4)150(241)167-69-117(206)175-110(71-200)149(240)188-105(61-114(159)203)145(236)182-96(153(244)245)34-23-25-51-157)183-131(222)90(33-22-24-50-156)178-133(224)92(42-46-113(158)202)180-142(233)102(58-86-65-162-73-168-86)187-144(235)104(60-88-67-164-75-170-88)192-152(243)125(78(5)6)196-136(227)95(45-49-120(211)212)181-139(230)98(57-85-38-40-89(201)41-39-85)174-116(205)68-166-130(221)109(70-199)193-146(237)107(63-122(215)216)190-143(234)103(59-87-66-163-74-169-87)186-132(223)91(35-26-52-165-154(160)161)179-140(231)100(55-83-29-16-12-17-30-83)184-134(225)93(43-47-118(207)208)176-129(220)81(10)172-138(229)106(62-121(213)214)173-115(204)37-21-20-36-112-127-111(72-247-112)194-155(246)198-127/h11-19,27-32,38-41,65-67,73-81,90-112,124-127,199-201H,20-26,33-37,42-64,68-72,156-157H2,1-10H3,(H2,158,202)(H2,159,203)(H,162,168)(H,163,169)(H,164,170)(H,166,221)(H,167,241)(H,171,228)(H,172,229)(H,173,204)(H,174,205)(H,175,206)(H,176,220)(H,177,219)(H,178,224)(H,179,231)(H,180,233)(H,181,230)(H,182,236)(H,183,222)(H,184,225)(H,185,232)(H,186,223)(H,187,235)(H,188,240)(H,189,226)(H,190,234)(H,191,242)(H,192,243)(H,193,237)(H,195,239)(H,196,227)(H,197,238)(H,207,208)(H,209,210)(H,211,212)(H,213,214)(H,215,216)(H,217,218)(H,244,245)(H4,160,161,165)(H2,194,198,246)/t80-,81-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,124-,125-,126-,127-/m0/s1
InChi Key
QQKZRRNHSHYENB-KLKIRDPGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    100 µg

    $163

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    Product Description

    Biotin-amyloid-β (1-28) peptide is a biotinylated peptide. Amyloid-β (1-28) (Aβ28) is a synthetic peptide that lacks 14 C-terminal amino acids and is more soluble than Aβ42.1 Aβ28 forms fibrils and plaques in vitro that are similar to those formed by Aβ42 and induces learning deficits in a passive avoidance task in rats.2,3,4 Biotin-amyloid-β (1-28) peptide is comprised of Aβ28 conjugated to biotin (Item No. 22582) at its amino terminus.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Syme, C.D., Nadal, R.C., Rigby, S.E., et al. Copper binding to the amyloid-beta (Aβ) peptide associated with Alzheimer’s disease. Folding, coordination geometry, pH dependence, stoichiometry, and affinity of Aβ(1-28): Insights from a range of complementary spectroscopic techniques. The Journal of Biological Chemisty 279(18), 18169-18177 (2004).

    2. Kirschner, D.A., Inouye, H., Duffy, L.K., et al. Synthetic peptide homologous to β protein from Alzheimer disease forms amyloid-like fibrils in vitro. Proc. Natl. Acad. Sci. USA 84(19), 6953-6957 (1987).

    3. Burdick, D., Soreghan, B., Kwon, M., et al. Assembly and aggregation properties of synthetic Alzheimer’s A4/β amyloid peptide analogs. The Journal of Biological Chemisty 267(1), 546-554 (1992).

    4. Alvarez, X.A., Miguel-Hidalgo, J.J., Fernández-Novoa, L., et al. Intrahippocampal injections of the beta-amyloid 1-28 fragment induces behavioral deficits in rats. Methods Find. Exp. Clin. Pharmacol. 19(7), 471-479 (1997).