A peptide agonist of PAR4
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(Ala1)-PAR4 (1-6) (mouse) (trifluoroacetate salt)

Item No. 27132

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-alanyl-L-tyrosyl-L-prolylglycyl-L-lysyl-L-phenylalanine, trifluoroacetate salt
Synonyms
  • H-Ala-Tyr-Pro-Gly-Lys-Phe-OH
  • AYPGKF
Molecular Formula
C34H47N7O8 • XCF3COOH
Formula Weight
681.8
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
OC(C(F)(F)F)=O.[H]N[C@H](C(N[C@H](C(N1CCC[C@H]1C(NCC(N[C@@H](CCCCN)C(N[C@H](C(O)=O)CC2=CC=CC=C2)=O)=O)=O)=O)CC3=CC=C(O)C=C3)=O)C
InChi Code
InChI=1S/C34H47N7O8.C2HF3O2/c1-21(36)30(44)39-26(18-23-12-14-24(42)15-13-23)33(47)41-17-7-11-28(41)32(46)37-20-29(43)38-25(10-5-6-16-35)31(45)40-27(34(48)49)19-22-8-3-2-4-9-22;3-2(4,5)1(6)7/h2-4,8-9,12-15,21,25-28,42H,5-7,10-11,16-20,35-36H2,1H3,(H,37,46)(H,38,43)(H,39,44)(H,40,45)(H,48,49);(H,6,7)/t21-,25-,26-,27-,28-;/m0./s1
InChi Key
XCJYZEYUJMUFTI-HKJXYENISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $75

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    1 mg

    $120

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    Product Description

    (Ala1)-PAR4 (1-6) is a synthetic peptide agonist of proteinase-activated receptor 4 (PAR4) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of mouse PAR4 and residues 60-65 of the full-length sequence with an alanine residue substituted for glycine at position 1/60.1 It is 10-fold more potent than PAR4 (1-6) (Item No. 27131), triggering [3H]inositol phosphate release from KOLF cells expressing human PAR4 at levels comparable to 30 nM thrombin (Item No. 13188) when used at a concentration of 500 μM. (Ala1)-PAR4 (1-6) induces aggregation of human platelets.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Faruqi, T.R., Weiss, E.J., Shapiro, M.J., et al. Structure-function analysis of protease-activated receptor 4 tethered ligand peptides. The Journal of Biological Chemisty 275(26), 19728-19734 (2000).

    2. Lidington, E.A., Steinberg, R., Kinderlerer, A.R., et al. A role for proteinase-activated receptor 2 and PKC-ε in thrombin-mediated induction of decay-accelerating factor on human endothelial cells. Am. J. Physiol. Cell Physiol. 289(6), 1437-1447 (2005).