A biotinylated caspase-3 and -7 inhibitor
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Biotin-DEVD-CHO (trifluoroacetate salt)

Item No. 27133

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]-L-α-aspartyl-L-α-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]-L-valinamide, trifluoroacetate salt
Synonyms
  • Biotin-Asp-Glu-Val-Asp-CHO
Molecular Formula
C28H42N6O12S • XCF3COOH
Formula Weight
686.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Formic Acid: 1 mg/ml
SMILES
OC(CC[C@H](NC([C@H](CC(O)=O)NC(CCCC[C@@H]1[C@@](NC(N2)=O)([H])[C@@]2([H])CS1)=O)=O)C(N[C@@H](C(C)C)C(N[C@H](C=O)CC(O)=O)=O)=O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C28H42N6O12S.C2HF3O2/c1-13(2)23(27(45)29-14(11-35)9-21(39)40)33-25(43)15(7-8-20(37)38)31-26(44)16(10-22(41)42)30-19(36)6-4-3-5-18-24-17(12-47-18)32-28(46)34-24;3-2(4,5)1(6)7/h11,13-18,23-24H,3-10,12H2,1-2H3,(H,29,45)(H,30,36)(H,31,44)(H,33,43)(H,37,38)(H,39,40)(H,41,42)(H2,32,34,46);(H,6,7)/t14-,15-,16-,17+,18+,23-,24+;/m0./s1
InChi Key
KNYCBYIWLOLJSR-XOFSVAJBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $145

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    Product Description

    Biotin-DEVD-CHO is a biotin-conjugated form of the caspase-3 and -7 inhibitor Ac-DEVD-CHO (Item No. 10017). It has been used for affinity purification of active caspase-3, -6, -7, and -8.1,2,3 Biotin-DEVD-CHO has also been used for detection of active caspase-3 in tissue samples and permeabilized cells using affinity labeling with streptavidin conjugates.4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kumar, S., and Dorstyn, L. Analysing caspase activation and caspase activity in apoptotic cells. Apoptosis: Methods and Protocols 3-17 (2009).

    2. Nicholson, D.W., Ali, A., Thornberry, N.A., et al. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376(6535), 37-43 (1995).

    3. Sohn, D., Schulze-Osthoff, K., and Jänicke, R.U. Caspase-8 can be activated by interchain proteolysis without receptor-triggered dimerization during drug-induced apoptosis. The Journal of Biological Chemisty 280(7), 5267-5273 (2005).

    4. Suria, H., Chau, L.A., Negrou, E., et al. Cytoskeletal disruption induces T cell apoptosis by a caspase-3 mediated mechanism. Life Sci. 65(25), 2697-26707 (1999).

    5. Huesmann, G.R., and Clayton, D.F. Dynamic role of postsynaptic caspase-3 and BIRC4 in zebra finch song-response habituation. Neuron 52(6), 1061-1072 (2006).