An inhibitor of caspase-8
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Boc-AEVD-CHO (trifluoroacetate salt)

Item No. 27148

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl-L-α-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]-L-valinamide, trifluoroacetate salt
Synonyms
  • Boc-Ala-Glu-Val-Asp-CHO
Molecular Formula
C22H36N4O10 • XCF3COOH
Formula Weight
516.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 1 mg/ml
SMILES
C[C@@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(O)=O)C=O)=O)C(C)C)=O)CCC(O)=O)=O)NC(OC(C)(C)C)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C22H36N4O10.C2HF3O2/c1-11(2)17(20(34)24-13(10-27)9-16(30)31)26-19(33)14(7-8-15(28)29)25-18(32)12(3)23-21(35)36-22(4,5)6;3-2(4,5)1(6)7/h10-14,17H,7-9H2,1-6H3,(H,23,35)(H,24,34)(H,25,32)(H,26,33)(H,28,29)(H,30,31);(H,6,7)/t12-,13-,14-,17-;/m0./s1
InChi Key
YLSRAFBNEHVRLB-PGKYVIAHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $75

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    1 mg

    $134

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    Product Description

    Boc-AEVD-CHO is an inhibitor of caspase-8 (Ki = 1.6 nM) that also inhibits caspase-1, -3, -6, and -9 (Kis = <12, 42, 52, and 48 nM, respectively).1 It is selective for these caspases over caspase-2, -4, -5, -7, and -10 (Kis = >10,000, 375, 438, 425, and 320 nM, respectively). Boc-AEVD-CHO has been used to study the potential interference of caspase-8 activity in micronuclei detection.2 It inhibits apoptosis induced by the aneugen nocodazole (Item No. 13857) in isolated human peripheral blood mononuclear cells (PBMCs) when used at a concentration of 300 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Garcia-Calvo, M., Peterson, E.P., Leiting, B., et al. Inhibition of human caspases by peptide-based and macromolecular inhibitors. The Journal of Biological Chemisty 273(49), 32608-32613 (1998).

    2. Decordier, I., Cundari, E., and Kirsch-Volders, M. Influence of caspase activity on micronuclei detection: A possible role for caspase-3 in micronucleation. Mutagenesis 20(3), 173-179 (2005).