An ECM peptide conjugated to biotin
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Product Categories

Product Type

Biochemicals
Peptides

Research Area

Cell Biology
ECM & Adhesion Molecules

Biotin Tripeptide-1

Item No. 27153

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]glycyl-L-histidyl-L-lysine
CAS Number
299157-54-3
Synonyms
  • Biotinoyl Tripeptide-1
  • Biotinyl-GHK
  • Biotinyl-Gly-His-Lys
Molecular Formula
C24H38N8O6S
Formula Weight
566.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 5mg/mLPBS (pH 7.2): 10mg/mL
SMILES
O=C(NCC(N[C@H](C(N[C@@H](CCCCN)C(O)=O)=O)CC1=CN=CN1)=O)CCCC[C@@H]2[C@@](NC(N3)=O)([H])[C@@]3([H])CS2
InChi Code
InChI=1S/C24H38N8O6S/c25-8-4-3-5-15(23(36)37)30-22(35)16(9-14-10-26-13-28-14)29-20(34)11-27-19(33)7-2-1-6-18-21-17(12-39-18)31-24(38)32-21/h10,13,15-18,21H,1-9,11-12,25H2,(H,26,28)(H,27,33)(H,29,34)(H,30,35)(H,36,37)(H2,31,32,38)/t15-,16-,17+,18+,21+/m0/s1
InChi Key
WCKVVODUWGBPQV-JDNULILRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    25 mg

    $36

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    50 mg

    $68

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    100 mg

    $123

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    250 mg

    $288

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    Product Description

    Biotin tripeptide-1 is an extracellular matrix (ECM) peptide that has been conjugated to biotin (Item No. 22582).1 It stimulates the production of collagen IV and laminin in dermal and epidermal cells ex vivo. Biotin tripeptide-1 localizes to the peri-pilial zone of isolated cultured human hair follicles, induces proliferation of keratinocytes, and increases hair growth by 58 and 121% compared with control follicles when used at concentrations of 2 and 5 ppm, respectively.2 It also prevents decreases in the collagen IV and laminin 5 bands of isolated cultured hair follicles.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gorouhi, F., and Maibach, H.I. Role of topical peptides in preventing or treating aged skin. Int. J. Cosmet. Sci. 31(5), 327-345 (2009).

    2. Lintner, K., and Maschamberlin, C. Formulations and method for treating baldness. (2006).