A stearoyl-CoA desaturase inhibitor
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CVT-12012

Item No. 27156

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-hydroxy-N-[2-[3-methyl-2-oxo-7-[[[3-(trifluoromethyl)phenyl]methyl]amino]-1(2H)-quinoxalinyl]ethyl]-acetamide
CAS Number
1018675-35-8
Molecular Formula
C21H21F3N4O3
Formula Weight
434.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:6): 0.14 mg/mlEthanol: 1 mg/ml
λmax
228, 379 nm
SMILES
CC(C(N1CCNC(CO)=O)=O)=NC(C1=C2)=CC=C2NCC3=CC(C(F)(F)F)=CC=C3
InChi Code
InChI=1S/C21H21F3N4O3/c1-13-20(31)28(8-7-25-19(30)12-29)18-10-16(5-6-17(18)27-13)26-11-14-3-2-4-15(9-14)21(22,23)24/h2-6,9-10,26,29H,7-8,11-12H2,1H3,(H,25,30)
InChi Key
HRAQDVZJYIAWOV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

    $268

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    25 mg

    $587

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    CVT-12012 is an orally bioavailable inhibitor of stearoyl-CoA desaturase (SCD; IC50 = 6.1 nM in HepG2 cells).1 It dose-dependently reduces levels of the SCD desaturation products palmitoleic acid (Item No. 10009871) and vaccenic acid in the plasma and liver of rats fed a high-sucrose diet. CVT-12012 (20 mg/kg) also reduces hepatic triglyceride levels in sucrose-fed rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Koltun, D.O., Zilbershtein, T.M., Migulin, V.A., et al. Potent, orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors. Bioorg. Med. Chem. Lett. 19(15), 4070-4074 (2009).