An active metabolite of bendamustine
Related Products
Parent Compound(s)
23693Bendamustine (hydrochloride)
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N-desmethyl Bendamustine

Item No. 27171

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-[bis(2-chloroethyl)amino]-1H-benzimidazole-2-butanoic acid
CAS Number
41515-13-3
Synonyms
  • nor-Bendamustine
Molecular Formula
C15H19Cl2N3O2
Formula Weight
344.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile:Methanol (1:1): solubleDMSO: soluble
SMILES
ClCCN(CCCl)C1=CC=C(N=C(CCCC(O)=O)N2)C2=C1
InChi Code
InChI=1S/C15H19Cl2N3O2/c16-6-8-20(9-7-17)11-4-5-12-13(10-11)19-14(18-12)2-1-3-15(21)22/h4-5,10H,1-3,6-9H2,(H,18,19)(H,21,22)
InChi Key
BPZIKXXNXMYQPN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

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    1 mg

    $422

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    Product Description

    N-desmethyl Bendamustine is an active metabolite of the DNA alkylating agent bendamustine (Item No. 23693).1 N-desmethyl Bendamustine is formed through demethylation of the benzimidazole ring in bendamustine by the cytochrome P450 (CYP) isoform CYP1A2. It inhibits proliferation of non-cancerous peripheral blood leukocytes (PBLs; IC50 = 45 µM) and SU-DHL-1, SU-DHL-9, and Daudi lymphoma cells (IC50s = 270, 170, and 120 µM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Teichert, J., Baumann, F., Chao, Q., et al. Characterization of two phase I metabolites of bendamustine in human liver microsomes and in cancer patients treated with bendamustine hydrochloride. Cancer Chemother. Pharmacol. 59(6), 759-770 (2007).