A phase II metabolite of carvedilol
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Parent Compound(s)
15418Carvedilol
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(R,S)-Carvedilol Glucuronide

Item No. 27173

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(9H-carbazol-4-yloxy)-1-[[[2-(2-methoxyphenoxy)ethyl]amino]methyl]ethyl β-D-glucopyranosiduronic acid
CAS Number
114869-83-9
Molecular Formula
C30H34N2O10
Formula Weight
582.6
Purity
≥95% (mixture of diastereomers)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: slightly soluble
SMILES
COC1=C(OCCNCC(COC2=C3C4=C(NC3=CC=C2)C=CC=C4)O[C@H]5[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O5)C=CC=C1
InChi Code
InChI=1S/C30H34N2O10/c1-38-21-10-4-5-11-22(21)39-14-13-31-15-17(41-30-27(35)25(33)26(34)28(42-30)29(36)37)16-40-23-12-6-9-20-24(23)18-7-2-3-8-19(18)32-20/h2-12,17,25-28,30-35H,13-16H2,1H3,(H,36,37)/t17?,25-,26-,27+,28-,30+/m0/s1
InChi Key
PUVQFGCELBOSRN-VKTJNCFWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $534

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    Product Description

    (R,S)-Carvedilol glucuronide is a racemic mixture of the carvedilol (Item No. 15418) metabolites (R)-carvedilol glucuronide and (S)-carvedilol glucuronide.1 (R)-Carvedilol glucuronide is formed via glucuronidation of (R)-carvedilol by the UDP-glucuronosyltransferase (UGT) isoforms UGT1A1 and UGT2B4. (S)-Carvedilol glucuronide is formed via glucuronidation of (S)-carvedilol by UGT2B4 and UGT2B7.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hanioka, N., Tanaka, S., Moriguchi, Y., et al. Stereoselective glucuronidation of carvedilol in human liver and intestinal microsomes. Pharmacology 90(3-4), 117-124 (2012).