An active metabolite of donepezil
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Parent Compound(s)
13245Donepezil
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6-O-desmethyl Donepezil

Item No. 27175

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,3-dihydro-6-hydroxy-5-methoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one
CAS Number
120013-56-1
Molecular Formula
C23H27NO3
Formula Weight
365.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: solubleMethanol: soluble
SMILES
O=C1C(CC2CCN(CC3=CC=CC=C3)CC2)CC4=CC(OC)=C(O)C=C41
InChi Code
InChI=1S/C23H27NO3/c1-27-22-13-18-12-19(23(26)20(18)14-21(22)25)11-16-7-9-24(10-8-16)15-17-5-3-2-4-6-17/h2-6,13-14,16,19,25H,7-12,15H2,1H3
InChi Key
DJRBBQJREIMIEU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $129

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    1 mg

    $180

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    5 mg

    $763

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    Product Description

    6-O-desmethyl Donepezil is an active metabolite of the acetylcholinesterase inhibitor donepezil (Item No. 13245).1 It is formed through dealkylation by the cytochrome P450 (CYP) isoform CYP2D6.2 It inhibits human ether a go-go (hERG) channels (IC50 = 1.5 µM in HEK293 cells expressing hERG).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chae, Y.J., Lee, H.J., Jeon, J.H., et al. Effects of donepezil on hERG potassium channels. Brain Res. 1597, 77-85 (2015).

    2. Matsui, K., Taniguchi, S., and Yoshimura, T. Identitication of cytochrome P450 involved in the metabolism of donepezil and in vitro drug interaction study in human liver microsomes. Drug Metab. Pharmacokinet. 15(2), 101-111 (2000).